Table 6 Multivariate model examining association between HIV infection and time to death among patients treated for tuberculosis, adjusted for baseline MDR-TB*
Characteristic | Multivariate model | Direct effect model | ||
|---|---|---|---|---|
(without mediators) | (with mediators) | |||
N = 1211, 101 deaths | N = 1192, 97 deaths | |||
Adjusted HR | Adjusted HR | |||
(95 % CI) | P value | (95 % CI) | P value | |
HIV positive | 6.36 (3.98–10.2) | <0.001 | 4.71 (2.87–7.73) | <0.001 |
Pediatric casea | 0.41 (0.06–3.01) | 0.381 | 0.32 (0.04–2.37) | 0.265 |
Female gender | 0.77 (0.48–1.25) | 0.288 | 0.84 (0.51–1.38) | 0.484 |
Unemployed | 1.95 (1.28–2.97) | 0.002 | 1.61 (1.05–2.47) | 0.029 |
Baseline sputum AFB smear positive | 2.05 (0.96–4.36) | 0.063 | 2.14 (1.00–4.61) | 0.051 |
Baseline MDR-TB | 1.40 (0.92–2.13) | 0.121 | 1.37 (0.89–2.10) | 0.150 |
Able to perform ADLs | 0.27 (0.16–0.45) | <0.001 | ||
Low BMIb | 2.09 (1.37–3.19) | 0.001 | ||
Dyspnea | 1.27 (0.79–2.07) | 0.326 | ||