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Table 1 Univariate logistic analyses, variables associated with all-cause 30-day in-hospital mortality

From: Complex clinical and microbiological effects on Legionnaires’ disease outcome; A retrospective cohort study

Parametersa, Alive (N = 60) Dead (N = 11) OR, 95 % CI P-value
Demography     
Age, years, mean ± SD 65.7 ± 15.5 74.6 ± 9.5 1.05, 1.0–1.10 0.08
Male sexb 42 (70.0) 8 (72.7) 0.88, 0.21–3.68 0.86
Predisposing conditions     
Nonec 7 (11.7) 0 - 1.00
Myocardial infarctionc,d 21 (35.0) 5 (45.5) 1.55, 0.42–5.68 0.51
Congestive heart failurec,d 8 (13.3) 4 (36.4) 3.71, 0.88–15.62 0.07
Chronic pulmonary diseasec,d 13 (21.7) 2 (18.2) 0.08, 0.15–4.19 0.80
Diabetesc,d 17 (28.3) 2 (18.2) 0.56, 0.11–2.87 0.49
Leukemiac,d 4 (6.7) 4 (36.4) 8.0, 1.63–39.35 0.01
Lymphomac,d 3 (5) 2 (18.2) 4.22, 0.62–28.87 0.14
Solid tumorc,d 6 (10) 0 - 0.58
Metastatic cancerc,d 2 (3.3) 1 (9.1) 2.9, 0.24–35.07 0.40
Steroid treatmentc, e 7 (11.7) 3 (27.3) 2.84, 0.61–13.30 0.19
Chemotherapyc, e 7 (11.7) 3 (27.3) 2.84, 0.61–13.30 0.19
Current smokerc 23 (38.3) 2 (18.2) 0.36, 0.07–1.80 0.21
Ever smokedc 35 (58.3) 6 (54.5) 0.86, 0.24–3.12 0.82
Hospitalization within 30 daysc 6 (10) 4 (36.4) 5.14, 1.16–22.82 0.03
Charlson comorbidity index, mean ± SD 2.3 ± 2.1 3.7 ± 2.1 1.33, 1.00–1.77 0.05
Laboratory variables at admission     
Oxygen saturation, %, mean ±SD 92.1 ± 5.2 88.3 ± 10.7 0.92, 0.83–1.02 0.12
Neutrophil count < 1.0 x109/Lc 2 (18.2)g 7 (10.0) 2.4, 0.40–14.31 0.34
Lymphocyte count < 1.0 x109/Lc 38 (64.4)g 5 (45.5) 0.46, 0.13–1.69 0.24
Creatinine level, μmol/L, mean ± SD 123.8 ± 70.7 168.0 ± 106.1 1.60, 0.88–2.89 0.12
Bilateral infiltrates on chest X-rayc 14 (23.3) 4 (36.4) 1.88, 0.48–7.36 0.37
Primary diagnosis by positive UATf 14 (23.3) 7 (63.6) 0.17, 0.04–0.68 0.01
Antibiotic therapy & outcome     
Appropriate therapy on day +1c 37 (61.7) 3 (27.3) 0.23, 0.06–0.98 0.05
Appropriate therapy on day +2 c 52 (86.7) 4 (36.4) 0.09, 0.02–0.37 0.001
Delay in appropriate therapy administration, days, mean ± SD 0.9 ± 1.8 4.2 ± 5.6 1.34, 1.08–1.67 0.01
Quinolones started on day +1c 17 (28.3) 3 (27.3) 1.13, 0.26–4.80 0.87
Quinolones started on day +2c 23 (38.3) 4 (36.4) 0.92, 0.24–3.49 0.90
ICU admissionc 12 (20.0) 9 (81.8) 18.00, 3.43–94.44 0.001
Invasive ventilation c 10 (16.7) 8 (72.7) 13.33, 3.00–59.19 0.001
  1. Abbreviations: OR odds ratio, CI confidence interval, SD standard deviation, ICU intensive care unit
  2. aNo.(%) unless otherwise stated
  3. bReference category: female sex
  4. cReference category: no
  5. dVariables included in the Charlson comorbidity score
  6. eWithin 30 days preceding hospitalization
  7. fReference category: primary diagnosis by positive culture
  8. gMissing data = 1