Table 5 Comparative performance of SSM versus LAM; and the combination of SSM and LAM versus SSM alone using composite reference standard, stratified by CD4 count
N = 457 | SSM versus LAM | Combined SSM with LAM versus SSM alone | |||||
|---|---|---|---|---|---|---|---|
SSM only | LAM only | p-value | SM only | LAM only | SM plus LAM | p-value | |
Sensitivity (95 % CI) | |||||||
CD4 (cells/μL) | |||||||
≤50 | 35.8 (26.8-45.5) | 60.6 (50.7-69.8) | <0.001 | 35.8 (26.8-45.5)* | 60.6 (50.7-69.8) | 67.6 (57.9-76.3)* | <0.001 |
51-100 | 30.0 (14.7-49.4) | 40.0 (22.7-59.4) | 0.417 | 30.0 (14.7-49.4) | 40.0 (22.7-59.4) | 50.0 (31.3-68.7) | >0.05 |
>100 | 17.2 (8.6-29.4) | 32.8 (21.0-46.3) | 0.054 | 17.2 (8.6-29.4)* | 32.8 (21.0-46.3) | 41.4 (28.6-55.1)* | 0.004 |
Specificity (95 % CI) | |||||||
CD4 (cells/μL) | |||||||
≤50 | 97.2 (92.2-99.4) | 97.2 (92.2-99.4) | >0.05 | 97.2 (92.2-99.4) | 97.2 (92.2-99.4) | 97.2 (92.2-99.4) | >0.05 |
51-100 | 100.0 (92.5-100.0) | 97.9 (88.7-99.9) | >0.05 | 100.0 (92.5-100.0) | 97.9 (88.7-99.9) | 97.9 (88.7-99.9) | >0.05 |
>100 | 100.0 (96.5-100.0) | 99.0 (94.8-100.0) | >0.05 | 100.0 (96.5-100.0) | 99.0 (94.8-100.0) | 99.0 (94.8-100.0) | >0.05 |