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Table 3 Relationship between pneumococcal vaccination status and pneumococcal carriage in children with asthma

From: Streptococcus pneumoniae colonisation in children and adolescents with asthma: impact of the heptavalent pneumococcal conjugate vaccine and evaluation of potential effect of thirteen-valent pneumococcal conjugate vaccine

  Vaccinated with PCV7 (n = 195) n (%) Not vaccinated against pneumococcus (n = 228) n (%) Crude OR (95 % CI) OR (95 % CI)a
Pneumococcal carrier status
 Any serotype
  Non-carriers 102 (44.2) 129 (55.8) 1 (reference) 1 (reference)
  Carriers 93 (48.4) 99 (51.6) 1.19 (0.81–1.74) 1.05 (0.70–1.58)
 Serotypes in PCV7
  Non-carriers 107 (43.8) 137 (56.2) 1 (reference) 1 (reference)
  Carriers 88 (49.2) 91 (50.8) 1.24 (0.84–1.82) 1.08 (0.72–1.62)
 Six additional serotypes in PCV13
  Non-carriers 162 (46.7) 185 (53.3) 1 (reference) 1 (reference)
  Carriers 33 (43.4) 43 (56.6) 0.88 (0.53–1.45) 0.76 (0.45–1.28)
Subgroup aged <10 years (n = 95) (n = 81)   
 Any serotype
  Non-carriers 45 (54.2) 38 (45.8) 1 (reference) 1 (reference)
  Carriers 50 (53.8) 43 (46.2) 0.98 (0.54–1.78) 1.01 (0.55–1.86)
 Serotypes in PCV7     
  Non-carriers 49 (55.1) 40 (44.9) 1 (reference) 1 (reference)
  Carriers 46 (52.9) 41 (47.1) 0.92 (0.51–1.66) 0.93 (0.51–1.72)
 Six additional serotypes in PCV13     
  Non-carriers 74 (54.4) 62 (45.6) 1 (reference) 1 (reference)
  Carriers 21 (52.5) 19 (47.5) 0.93 (0.46–1.88) 0.98 (0.47–2.03)
Subgroup aged 10–14 years (n = 87) (n = 120)   
 Any serotype
  Non-carriers 47 (40.2) 70 (59.8) 1 (reference) 1 (reference)
  Carriers 40 (44.4) 50 (55.6) 1.19 (0.68–2.08) 1.08 (0.61–1.94)
 Serotypes in PCV7
  Non-carriers 47 (38.8) 74 (61.2) 1 (reference) 1 (reference)
  Carriers 40 (46.5) 46 (53.5) 1.37 (0.78–2.40) 1.22 (0.68–2.20)
 Six additional serotypes in PCV13
  Non-carriers 76 (43.7) 98 (56.3) 1 (reference) 1 (reference)
  Carriers 11 (33.3) 22 (66.7) 0.65 (0.29–1.41) 0.54 (0.23–1.26)
  1. 95 % CI 95 % confidence interval; OR odds ratio; PCV7 7-valent pneumococcal conjugate vaccine; PCV13 13-valent pneumococcal conjugate vaccine
  2. aORs adjusted for age (as a continuous term), gender, ethnicity, number of siblings, and parental smoking