Skip to main content

Table 5 Association of IL-23R polymorphisms and drug-sensitivity and conversion of sputum culture in pulmonary TB patients

From: The variations of IL-23R are associated with susceptibility and severe clinical forms of pulmonary tuberculosis in Chinese Uygurs

dbSNP ID/ Genotype Drug-sensitivity (N = 250) OR (95 % CI) Months of treatment for Negative culture (N =250) OR (95 % CI)
CNV   Drug-sensitive Drug-resistant   ≤2 months > 2 months  
   N = 172 n (%) N = 78 n (%)   N = 195 n (%) N = 55 n (%)  
rs1884444 TT 72 (41.9) 31 (39.7) 1 79 (40.5) 24 (43.6) 1
  GG + GT 100 (58.1) 47 (60.3) 1.09 (0.63–1.88) 116 (59.5) 31 (56.4) 0.88 (0.48–1.61)
rs10889664 CC 85 (49.4) 38 (48.7) 1 96 (49.2) 27 (49.1) 1
  TT + CT 87 (50.6) 40 (51.3) 1.03 (0.60–1.76) 99 (50.8) 28 (50.9) 1.01 (0.55–1.83)
rs11465788 TT 73 (42.1) 32 (41.0) 1 83 (42.6) 22 (40.0) 1
  CC + CT 99 (57.9) 46 (59.0) 1.06 (0.62–1.83) 112 (57.4) 33 (60.0) 1.11 (0.60–2.05)
rs7518660 GG 8 (4.7) 4 (5.1) 1 9 (4.6) 3 (5.5) 1
  AA + AG 164 (95.3) 74 (94.9) 0.90 (0.29–3.09) 186 (95.4) 52 (94.5) 0.84 (0.22–3.21)
rs11465802 CC 117 (32.0) 31 (60.3) 1 116 (59.5) 32 (58.2) 1
  AA + AC 55 (68.0) 47 (39.7) 3.23 (1.85–5.62) 79 (40.5) 23 (41.8) 1.06 (0.58–1.94)
rs10889677 AA 37 (21.5) 16 (20.5) 1 41 (21.0) 12 (21.8) 1
  CC + AC 135 (78.5) 62 (79.5) 1.06 (0.55–2.05) 154 (79.0) 43 (78.2) 0.95 (0.46–1.97)
CNV CN = 2 138 (80.2) 62 (79.5) 1 157 (80.5) 43 (78.2) 1
  CN = 1, 3, 4 34 (19.8) 16 (20.5) 1.05 (0.54–2.04) 38 (19.5) 12 (21.8) 1.15 (0.56–2.40)
  1. OR odds ratio, CI confidence interval