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Table 3 Comparison of immune dysregulation between bacterial sepsis and tuberculosis

From: Monocyte unresponsiveness and impaired IL1β, TNFα and IL7 production are associated with a poor outcome in Malawian adults with pulmonary tuberculosis

Bacterial Sepsis Malawian TB Patients
↓monocyte HLA-DR expression associated with secondary infection [2, 4] Variable monocyte HLA-DR expressiona
HLA-DR expression correlates with TNFα production [24] No correlation between monocyte HLA-DR expression and TNFα production
Correlation between monocyte HLA-DR and CD86 expression [6, 25] Correlation between monocyte HLA-DR and CD86 expression
↓CD86 expression associated with increased severity of inflammation [7, 25] Widely variable monocyte CD86 expressiona
Expansion of CD14loCD16hi monocyte population [26] Expansion of CD14loCD16hi monocyte population
CD14loCD16hi monocytes major TNFα producers [11] ‘Classical’ CD14hiCD16neg monocytes major TNFα producers
  1. aSample size insufficient to correlate with clinical outcome