Table 2 Correlation of TNFα responses to TB antigens and TLR ligands
TLR agonist (18 h) | Corresponding TLR receptor (Spearman’s R and p-value) | ||
|---|---|---|---|
Ligand | Receptor | H37Rv (TB) | LPS (bacterial sepsis) |
Ultrapure LPS | TLR4 | 0.52, p = 0.0024 | 0.59, p = 0.0008 |
Pam2CSK4 | TLR2 | 0.16, not significant | 0.38, p = 0.01 |
Pam3CSK4 | TLR1/2 | 0.78, p < 0.0001 | 0.69, p = 0.0001 |
Poly(I:C) | TLR3 | 0.54, p = 0.0018 | 0.66, p = 0.0003 |