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Table 2 Correlation of TNFα responses to TB antigens and TLR ligands

From: Monocyte unresponsiveness and impaired IL1β, TNFα and IL7 production are associated with a poor outcome in Malawian adults with pulmonary tuberculosis

TLR agonist (18 h) Corresponding TLR receptor (Spearman’s R and p-value)
Ligand Receptor H37Rv (TB) LPS (bacterial sepsis)
Ultrapure LPS TLR4 0.52, p = 0.0024 0.59, p = 0.0008
Pam2CSK4 TLR2 0.16, not significant 0.38, p = 0.01
Pam3CSK4 TLR1/2 0.78, p < 0.0001 0.69, p = 0.0001
Poly(I:C) TLR3 0.54, p = 0.0018 0.66, p = 0.0003