Table 4 Mutations acquired by patients failing second line treatment
From: Outcome of patients on second line antiretroviral therapy under programmatic condition in India
Patient ID | Gene Bank Accession No. | Duration of second line treatment (months) | Adherence during 2nd line treatment | Subtype | Major PI mutation | Minor PI mutation | NRTI mutation | NNRTI mutation | GSS score | Etravirine sensitivity score |
|---|---|---|---|---|---|---|---|---|---|---|
SL-1 | KJ933454 | 46 | >95 % | C | M46I, I47A, I50IL, I84V | A71V | M41L, D67N, K70R, L74IL, M184V, T215Y, K219Q | K103N, K238KN | 0 | 0 |
SL-2 | KJ933455 | 13 | >95 % | C | NONE | NONE | M41L, D67N, M184V, T215F, K219W | Y181V, G190A | 1.25 | 4 |
SL-3 | KJ933456 | 23 | >95 % | C | M46I, N88S | L24I, Q58E, A71V | M41L, K65R, K70T, M184V | A98G, K101E, G190A | 0 | 3 |
SL-4 | KJ933457 | 9 | >95 % | C | NONE | NONE | M184V | K101E, G190A | 2 | 2 |
SL-5 | KJ933458 | 20 | >95 % | C | M46I | L23IL | D67N, V75M, M184V | Y181C | 1.25 | 2.5 |
SL-6 | KJ933459 | 24 | >95 % | C | None | K20I, L90LW | None | V108IV, Y181C, H221Y | 3 | 2.5 |
SL-9 | KJ933461 | 25 | <95 % | C | M46I, I50L, V82A | L33FL, A71AV, G73S, N83DN | M41L, D67N, V75M, M184V, L210W, T215Y, K219N | A98G, K103N | 0 | 1 |
SL-11 | KJ933463 | 9 | >95 % | C | M46I, N88NS | K20IT, E35DEG, A71AT, T74S | M41L, M184V, L210W, T215Y, K219KN | K101H, Y181CFIS, G190A | 0 | 7.5 |
SL-12 | KJ933464 | 14 | >95 % | C | NONE | K20KT, G73S | M41L, D67E, V75M, M184V, L210W, T215Y | V90I, V108I, Y181C | 0.5 | 3.5 |
SL-13 | KJ933465 | 10 | >95 % | A1C | I84IV | L23I, A71V | M41L, D67N, L74I, V75M, M184V, L210W, T215Y, K219N | A98G, K103N, G190 | 0 | 2 |
SL-14 | KJ933466 | 9 | <95 % | C | None | None | None | None | 3 | 0 |
SL-15 | KJ933467 | 20 | >95 % | C | NONE | NONE | M41L, D67N, V75M, M184V, T215Y, K219N | V90I, K103N | 1.25 | 1 |
SL-16 | KJ933468 | 20 | >95 % | C | NONE | T74S | M41L, K70R, L74I, M184V, T215F, K219W | V106M, V108I, Y181C, F227L | 1.25 | 2.5 |
SL-19 | KJ933469 | 12 | <95 % | C | NONE | NONE | NONE | K101E | 3 | 1 |
SL-20 | KJ933470 | 36 | >95 % | C | M46I | NONE | M41L, D67N, T69D, V75M, M184V, L210W, T215Y | A98G, K101EK, V108I, V179IT, G190A, F227L | 0.75 | 4 |
SL-21 | KJ933471 | 18 | <95 % | C | N88S | L10F, K20T, Q58E | D67N, T69D, K70R, M184V, T215F, K219Q | K101E, Y181C | 0.25 | 3.5 |