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Table 2 Bivariate and multivariate cox proportional hazards analyses of factors associated with art discontinuation among a sample of injection drug users in vancouver, canada (n = 794)

From: Association of patterns of methadone use with antiretroviral therapy discontinuation: a prospective cohort study

 

Unadjusted Hazard Ratio (HR)

Adjusted Hazard Ratio (AHR)

Variable

HR

95 % CI

p value

AHR

95 % CI

p value

MMT

      

 Current MMT

1.00

---

---

1.00

---

---

 Not on MMT

1.36

1.12–1.65

0.002

1.44

1.19–1.73

<0.001

 Discontinued MMT

3.03

2.12–4.33

<0.001

1.82

1.27–2.60

0.001

Gender

      

 (Male vs. female)

0.71

0.58–0.86

<0.001

---

---

---

Age

      

 (Per 10 years older)

0.49

0.43–0.55

<0.001

0.59

0.52–0.66

<0.001

Ethnicity

      

 (Caucasian vs. other)

0.78

0.64–0.95

0.015

---

---

---

Homelessnessa

      

 (Yes vs. no)

1.94

1.57–2.39

<0.001

1.53

1.24–1.87

<0.001

Sex work involvementa

      

 (Yes vs. no)

1.64

1.28–2.10

<0.001

---

---

---

Daily heroin injectiona

      

 (Yes vs. no)

2.59

2.09–3.21

<0.001

1.70

1.39–2.08

<0.001

Daily cocaine injectiona

      

 (Yes vs. no)

2.10

1.72–2.58

<0.001

---

---

---

Daily crack cocaine smokinga

      

 (Yes vs. no)

1.40

1.17–1.68

<0.001

---

---

---

Daily alcohol use

      

 (Yes vs. no)

1.63

1.27–2.09

<0.001

---

---

---

Protease inhibitor initial regimena

      

 (Yes vs. no)

0.97

0.79–1.19

0.771

---

---

---

Baseline CD4 count

      

 (Per 100 cells/mm3)

0.95

0.90–0.99

0.025

1.03

0.98–1.07

0.234

Baseline viral load

      

 (Per log10 copies/mL)

1.49

1.40–1.58

<0.001

1.39

1.29–1.50

<0.001

Physician HIV experienceb

      

 (Per # prev. patients)

1.00

1.00–1.00

0.074

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---

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  1. aRefers to behaviors in the previous six months. bRefers to number of total HIV patients physician has treated prior to initial visit with participant