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Table 2 Bivariate and multivariate cox proportional hazards analyses of factors associated with art discontinuation among a sample of injection drug users in vancouver, canada (n = 794)

From: Association of patterns of methadone use with antiretroviral therapy discontinuation: a prospective cohort study

  Unadjusted Hazard Ratio (HR) Adjusted Hazard Ratio (AHR)
Variable HR 95 % CI p value AHR 95 % CI p value
MMT       
 Current MMT 1.00 --- --- 1.00 --- ---
 Not on MMT 1.36 1.12–1.65 0.002 1.44 1.19–1.73 <0.001
 Discontinued MMT 3.03 2.12–4.33 <0.001 1.82 1.27–2.60 0.001
Gender       
 (Male vs. female) 0.71 0.58–0.86 <0.001 --- --- ---
Age       
 (Per 10 years older) 0.49 0.43–0.55 <0.001 0.59 0.52–0.66 <0.001
Ethnicity       
 (Caucasian vs. other) 0.78 0.64–0.95 0.015 --- --- ---
Homelessnessa       
 (Yes vs. no) 1.94 1.57–2.39 <0.001 1.53 1.24–1.87 <0.001
Sex work involvementa       
 (Yes vs. no) 1.64 1.28–2.10 <0.001 --- --- ---
Daily heroin injectiona       
 (Yes vs. no) 2.59 2.09–3.21 <0.001 1.70 1.39–2.08 <0.001
Daily cocaine injectiona       
 (Yes vs. no) 2.10 1.72–2.58 <0.001 --- --- ---
Daily crack cocaine smokinga       
 (Yes vs. no) 1.40 1.17–1.68 <0.001 --- --- ---
Daily alcohol use       
 (Yes vs. no) 1.63 1.27–2.09 <0.001 --- --- ---
Protease inhibitor initial regimena       
 (Yes vs. no) 0.97 0.79–1.19 0.771 --- --- ---
Baseline CD4 count       
 (Per 100 cells/mm3) 0.95 0.90–0.99 0.025 1.03 0.98–1.07 0.234
Baseline viral load       
 (Per log10 copies/mL) 1.49 1.40–1.58 <0.001 1.39 1.29–1.50 <0.001
Physician HIV experienceb       
 (Per # prev. patients) 1.00 1.00–1.00 0.074 --- --- ---
  1. aRefers to behaviors in the previous six months. bRefers to number of total HIV patients physician has treated prior to initial visit with participant