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Table 3 Number of deaths, cases and case fatality ratio (CFR, %) by age group for the 840 MRU-confirmed cases that did not link to a HES meningococcal disease ICD10 code (MRU+/HESA39-)

From: Invasive meningococcal disease in England: assessing disease burden through linkage of multiple national data sources

Age group

Linked+/Infection-related

NHS number+/Unlinked

Linked+/Another-pathogen

Linked+/Not-infection

No NHS number

All cases

<1y

5/50 (10.0 %)

20/43 (46.5 %)

0/9 (0.0 %)

1/2 (50.0 %)

7/63 (11.1 %)

33/167 (19.8 %)

1-4y

0/62 (0.0 %)

16/33 (48.5 %)

2/23 (8.7 %)

0/4 (0.0 %)

5/77 (6.5 %)

23/199 (11.6 %)

5-14y

0/33 (0.0 %)

5/16 (31.3 %)

0/5 (0.0 %)

0/3 (0.0 %)

2/34 (5.9 %)

7/91 (7.7 %)

15-24y

5/25 (20.0 %)

10/51 (19.6 %)

1/4 (25.0 %)

0/2 (0.0 %)

3/37 (8.1 %)

19/119 (16.0 %)

25-44y

1/11 (9.1 %)

6/25 (24.0 %)

0/2 (0.0 %)

0/2 (0.0 %)

2/37 (5.4 %)

9/77 (11.7 %)

45-64y

1/21 (4.8 %)

12/25 (48.0 %)

0/6 (0.0 %)

0/4 (0.0 %)

2/18 (11.1 %)

15/74 (20.3 %)

≥65y

5/46 (10.9 %)

5/17 (29.4 %)

3/22 (13.6 %)

2/9 (22.2 %)

1/13 (7.7 %)

16/107 (15.0 %)

Total

17/248 (6.9 %)

74/210 (35.2 %)

6/71 (8.5 %)

3/26 (11.5 %)

22/285 (7.7 %)a

122/840 (14.5 %)a

Cause of death on death registration record

Bacterial meningitis (2); Viral meningitis (1); Encephalitis (1); IMD (all others)

IMD (all fatalities)

Bacterial Meningitis (1); IMD (all others)

IMD (all fatalities)

Bacterial Meningitis (1); IMD (all others)

 
  1. The highest case fatality was observed for the MRU-confirmed cases with NHS numbers that did not link to a HES admission for meningococcal disease (NHS number+/Unlinked). Notably, the ONS death registrations recorded meningococcal disease as the cause of death for nearly all fatal cases irrespective of the linkage status among these MRU+/HESA39- cases IMD, Invasive meningococcal Disease; MRU, meningococcal reference unit; HES, Hospital Episode Statistic; NHS, National Health Service
  2. aThe age of six MRU-confirmed cases with no NHS number was not known