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Table 3 Number of deaths, cases and case fatality ratio (CFR, %) by age group for the 840 MRU-confirmed cases that did not link to a HES meningococcal disease ICD10 code (MRU+/HESA39-)

From: Invasive meningococcal disease in England: assessing disease burden through linkage of multiple national data sources

Age group Linked+/Infection-related NHS number+/Unlinked Linked+/Another-pathogen Linked+/Not-infection No NHS number All cases
<1y 5/50 (10.0 %) 20/43 (46.5 %) 0/9 (0.0 %) 1/2 (50.0 %) 7/63 (11.1 %) 33/167 (19.8 %)
1-4y 0/62 (0.0 %) 16/33 (48.5 %) 2/23 (8.7 %) 0/4 (0.0 %) 5/77 (6.5 %) 23/199 (11.6 %)
5-14y 0/33 (0.0 %) 5/16 (31.3 %) 0/5 (0.0 %) 0/3 (0.0 %) 2/34 (5.9 %) 7/91 (7.7 %)
15-24y 5/25 (20.0 %) 10/51 (19.6 %) 1/4 (25.0 %) 0/2 (0.0 %) 3/37 (8.1 %) 19/119 (16.0 %)
25-44y 1/11 (9.1 %) 6/25 (24.0 %) 0/2 (0.0 %) 0/2 (0.0 %) 2/37 (5.4 %) 9/77 (11.7 %)
45-64y 1/21 (4.8 %) 12/25 (48.0 %) 0/6 (0.0 %) 0/4 (0.0 %) 2/18 (11.1 %) 15/74 (20.3 %)
≥65y 5/46 (10.9 %) 5/17 (29.4 %) 3/22 (13.6 %) 2/9 (22.2 %) 1/13 (7.7 %) 16/107 (15.0 %)
Total 17/248 (6.9 %) 74/210 (35.2 %) 6/71 (8.5 %) 3/26 (11.5 %) 22/285 (7.7 %)a 122/840 (14.5 %)a
Cause of death on death registration record Bacterial meningitis (2); Viral meningitis (1); Encephalitis (1); IMD (all others) IMD (all fatalities) Bacterial Meningitis (1); IMD (all others) IMD (all fatalities) Bacterial Meningitis (1); IMD (all others)  
  1. The highest case fatality was observed for the MRU-confirmed cases with NHS numbers that did not link to a HES admission for meningococcal disease (NHS number+/Unlinked). Notably, the ONS death registrations recorded meningococcal disease as the cause of death for nearly all fatal cases irrespective of the linkage status among these MRU+/HESA39- cases IMD, Invasive meningococcal Disease; MRU, meningococcal reference unit; HES, Hospital Episode Statistic; NHS, National Health Service
  2. aThe age of six MRU-confirmed cases with no NHS number was not known