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Table 6 Univariate and multivariate analyses of factors predicting recurrence-free survival of penicilliosis among HIV-negative patients

From: Differences in clinical characteristics and prognosis of Penicilliosis among HIV-negative patients with or without underlying disease in Southern China: a retrospective study

Factor Univariate Multivariate
HR 95 % CI P HR 95 % CI P
Age > 60 or < 3 years 0.700 0.274–1.792 0.457    
Underlying diseases 0.228 0.064–0.813 0.014* 0.289 0.074-1.132 0.075
Fever 0.300 0.065–1.378 0.122    
Lymphadenopathy 2.074 0.601–7.155 0.249    
Hepatomegaly 0.374 0.118–1.185 0.095    
Splenomegaly 0.606 0.217–1.697 0.341    
Cutaneous lesions 0.575 0.225–1.471 0.248    
Cough 6.568 0.861–50.100 0.069    
Dyspnoea 1.265 0.479–3.344 0.635    
Anaemia 1.525 0.439–5.303 0.507    
Osteolysis 0.581 0.209–1.618 0.299    
Thoracalgia 1.204 0.453–3.200 0.710    
Bloody stools/diarrhoea 1.122 0.326–3.869 0.855    
Duration of diagnosis 1.026 0.405–2.597 0.957    
WBC > 10*109/L 0.628 0.181–2.177 0.463    
Neutrophils > 6.3*109/L 0.573 0.205–1.604 0.289    
Lymphocytes < 1.10*109/L 2.093 0.730–6.004 0.169    
Haemoglobin < 130 g/L 1.082 0.410–2.855 0.874    
ALT > 45U/L 2.941 0.608–14.230 0.180    
ALB < 55U/L 1.274 0.288–5.627 0.749    
CD4 < 410/ul 1.003 0.998–1.008 0.289    
CD8 < 190 /ul 0.994 0.985–1.002 0.146    
CD4% < 31.98 % 3.033 1.186–7.754 0.015* 1.224 0.305–4.921 0.775
CD8% < 20.70 % 0.654 0.256–1.121 0.374    
T cell% < 64.2 % 2.963 1.146–7.659 0.019* 1.950 0.504–7.539 0.333
IgG < 7 g/L 0.800 0.181–3.536 0.769    
Chest imaging 0.708 0.251–1.999 0.515    
  1. Patients with Penicillium marneffei infection were divided into two groups; Group D included patients with underlying disease, and Group ND included patients without underlying disease
  2. ALB serum albumin, ALT alanine aminotransferase, CI confidence interval, HR hazard ratio, WBC white blood cell, CD4 CD4 T cell count, CD8 CD8 T cell count, CD4% CD4 cell percentage, CD8% CD8 cell percentage, T cell% T lymphocyte cell percentage, IgG serum immunoglobulin G. *P < 0.05