Differential outcome of an antimicrobial stewardship audit and feedback program in two intensive care units: a controlled interrupted time series study

Table 1 Patient characteristics for those in the trauma and neurosurgery intensive care unit and medical surgical intensive care unit during the pre- and post-intervention periods.

Unit	Characteristic	Pre-intervention period	Post-intervention period	p-value
TNICU
	Admissions	n = 1330	n = 1387
	Age, mean (SD)	55 (18) ^b	56 (18)	0.12
	Male	757 (57)	801 (58)	0.66
	Admitting diagnosis			0.0086
	Neurological	879 (66)	937 (68)
	Trauma	327 (25)	364 (26)
	Other	124 (9)	86 (6)
	Ventilator utilization ratio	0.59	0.60	0.80
	Multiple organ dysfunction score, mean (SD)	2.39 (0.34)	2.32 (0.24)	0.56^a
	Febrile respiratory illness rate, cases per 1000 patient days	0.5	0.3	0.66
	Influenza rate, cases per 1000 patient days	0	0	1.00
	Patient days attributable to cystic fibrosis	0 (0)	0 (0)	–
MSICU
	Admissions	n = 1305	n = 1369
	Age, mean (SD)	61 (17)	59 (18)	0.016
	Male	784 (60)	833 (61)	0.68
	Admitting diagnosis			0.0082
	Respiratory	192 (15)	265 (19)
	Gastrointestinal	142 (11)	123 (9)
	Neurological	88 (7)	95 (7)
	Other	883 (68)	886 (65)
	Ventilator utilization ratio	0.69	0.69	0.77
	Multiple organ dysfunction score, mean (SD)	4.26 (0.38)	3.83 (0.33)	0.0061^a
	Febrile respiratory illness rate, cases per 1000 patient days	21.4	17.6	0.099
	Influenza rate, cases per 1000 patient days	1.7	2.1	0.52
	Patient days attributable to cystic fibrosis	68 (1)	277 (4)	<0.0001

Data are number (%) unless otherwise indicated. All p-values calculated using Chi-square unless otherwise noted. SD, standard deviation; TNICU, trauma and neurosurgery intensive care unit; MSICU, medical surgical intensive care unit. ^at-test; ^b2 data points missing

ISSN: 1471-2334