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Table 1 Characteristics of S. pneumoniae-positive cases (N = 36) hospitalized at Chris Hani Baragwanath Academic Hospital for which a serotype/serogroup could be identified by the Quellung reaction and/or the molecular serotyping assay, Soweto, South Africa, 2009-2012a

From: Assessing the impact of pneumococcal conjugate vaccines on invasive pneumococcal disease using polymerase chain reaction-based surveillance: an experience from South Africa

Age group
(in years)
HIV serostatus lytA
Ct-value
Serotype/serogroup
Quellung reaction Molecular serotyping assay
lytA Ct-value ≤30
 25–44 Pos 25 19 F 19B/19 F
 45–64 Pos 26 1 1
 <2 Pos 27 10Ac Neg42
 25–44 Pos 27 19 F 19B/F
 25–44 Unknown 27 Not availableb 18A/B/C
 25–44 Pos 27 19A 19A
 25–44 Pos 28 19A 19A
 25–44 Pos 28 19 F 19B/F
 25–44 Pos 29 19A 19A
 25–44 Pos 29 19A 19A
 25–44 Pos 30 19A 19A
lytA Ct-value 31–34
 25–44 Pos 31 3 3
 45–64 Unknown 31 19A 19A
 25–44 Pos 31 1 1
 25–44 Pos 32 12 F 12A/B/F
 25–44 Neg 32 19A 19A
 45–64 Pos 33 4 4
 25–44 Pos 33 Not availableb 19A
 25–44 Neg 34 1 1
 25–44 Pos 34 Not availableb 1
 25–44 Pos 34 1d Neg42
 45–64 Pos 34 19A 19A
lytA Ct-value ≥35
 5–24 Pos 35 9 V 9A/L/N/V
 <2 Pos 35 23 F 23 F
 5–24 Pos 35 19Ad Neg42
 25–44 Pos 35 1d Neg42
 <2 Neg 36 6A 6A/B
 <2 Unknown 36 6B 6A/B
 5–24 Pos 36 18Cd Neg42
 25–44 Pos 37 19Ad Neg42
 2–4 Neg 37 14d Neg42
 25–44 Pos 37 Not availableb 1
 25–44 Pos 38 1d Neg42
 25–44 Pos 38 23Ac Neg42
 2–4 Pos 39 6Ad Neg42
 <2 Neg 39 19Ae 18A/B/Ce
  1. Abbreviations: HIV: human immunodeficiency virus; Ct-value: cycle threshold value; Neg42: samples that tested negative for the 42 serotypes detected by the serotyping assay
  2. a Discrepant or missing serotype/serogroup results are in bolt font
  3. b Isolate not available for serotyping using the Quellung reaction
  4. c Serotype not included in the molecular serotyping assay
  5. d Serotype included in the molecular serotyping assay