Reference Measures of In-Vitro Activity and Pharmacokinetics | Simultaneous Serum and Pleural Cmax and Tmax in CTE | ||||||||
---|---|---|---|---|---|---|---|---|---|
Drug | Cmaxa | Tmaxa | MICb | Cmax/MIC | Dose (mg) | Cmax (mg/L) | Tmax (hrs)c | ||
(mg/L) | (hrs) | (mg/L) | (Ref.) | Serum | Pleural Fluid | Serum | Pleural Fluid | ||
Isoniazid | 3-6 | 1-2 | 0.125 | 24.0-48.0 | 300 (12) | 3.25 | 0.96 | 1 (6) | 6 (6) |
(300 mg) | 400 (P1) | 3.49 | 1.75 | 1 (6) | 6 (6) | ||||
900 (P2) | 12.77 | 5.12 | 2 (8) | 6 (8) | |||||
Rifampin | 8-24 | 2 | 0.03125 | 256.0-768.0 | 600 (7) | 21.75 | 0.87 | 2 (10) | 10 (10) |
(600 mg) | 600 (12) | 8.01 | 0.48 | 2 (6) | 6 (6) | ||||
600 (P1) | 2.20 | 1.02 | 2 (6) | 6 (6) | |||||
1200 (P2) | 12.92 | 1.57 | 2 (8) | 8 (8) | |||||
Pyrazinamide | 20-50 | 1-2 | 50.000 | 0.4-1.0 | 2000 (12) | 45.82 | 22.68 | 1 (6) | 6 (6) |
(20–25 mg/kg) | 2000 (P1) | 34.99 | 29.85 | 6 (6) | 6 (6) | ||||
Ethambutol | 2-6 | 1-2 | 1.000 | 2.0-6.0 | 1200 (7) | 1.60 | 1.90 | 6 (10) | 6 (10) |
(20–25 mg/kg) | 1400 (P1) | 3.31 | 1.60 | 6 (6) | 6 (6) | ||||
Moxifloxacin | 3-5 | 2 | 0.250 | 12.0-20.0 | 600 (P1) | 3.80 | 1.08 | 6 (6) | 6 (6) |
(400 mg) | 600 (7)d | 10.08 | 4.84 | 2 (10) | 10 (10) |