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Table 3 Diagnostic accuracy results of the NS1 Ag-based tests on the viral serotype, serological status and clinical severity

From: Evaluation of the diagnostic accuracy of nonstructural protein 1 Ag-based tests for dengue virus in Asian population: a meta-analysis

  ELISA IC
  Platelia Panbio Overall Strip
Overall     
 No. of study 11 5 14 7
 Sensitivity % (95 % CI) 66.2 (64.1–68.2) 54 (50.1–57.9) 63.3 (61.5–65.1) 72.9 (70.1–75.5)
 Specificity % (95 % CI) 97.3 (96.1–98.2) 97.2 (95.2–98.6) 97.3 (96.3–98.1) 99.1 (98.2–99.6)
 Heterogeneity % (I2) 84.1 79.8 82.4 40.5
DENV serotypes     
 DENV1     
  No. of study 7 2 8 3
  Sensitivity % (95 % CI) 83.7 (79.7–87.1) 73.7 (65.5–80.9) 81.2 (77.7–84.4) 75.9 (70.1–81)
  Heterogeneity % (I2) 82.5 89.6 84 57.8
 DENV2     
  No. of study 7 2 8 4
  Sensitivity % (95 % CI) 56.9 (51.9–61.8) 71.8 (60.5–81.4) 59.3 (54.8–63.7) 69 (63–74.5)
  Heterogeneity % (I2) 88.6 0 86.4 70.4
 DENV3     
  No. of study 6 2 7 4
  Sensitivity % (95 % CI) 69.9 (64.8–74.6) 63.3 (48.3–76.6) 69.1 (64.3–73.5) 81.9 (75.5–87.2)
  Heterogeneity % (I2) 82.3 15.3 76.9 75.5
 DENV4     
  No. of study 4 0 4 0
  Sensitivity % (95 % CI) 42.9(32.1–54.1)   42.9 (32.1–54.1)  
  Heterogeneity % (I2) 57.1   57.1  
Serological status     
 Primary     
  No. of study 7 2 8 2
  Sensitivity % (95 % CI) 95.1 (92.6–96.9) 72.6 (65.6–78.9) 88.4 (85.7–90.8) 87.3 (83.6–90.5)
  Heterogeneity % (I2) 56.8 29.2 89.1 94.6
 Secondary     
  No. of study 7 3 9 2
  Sensitivity % (95 % CI) 63 (59.5–66.4) 50.8 (43.5–58) 60.6 (57.4–63.6) 64 (53.2–73.9)
  Heterogeneity % (I2) 95.8 0 94.1 88.1
Clinical severity     
 Dengue Fever     
  No. of study 4 1 5 1
  Sensitivity % (95 % CI) 72.1 (67.6–76.3) 51 (37–64) 69.5 (65.2–73.6) 89 (67–99)
  Heterogeneity % (I2) 73.9   81.7  
 Dengue Hemorrhagic Fever     
  No. of study 4 1 5 1
  Sensitivity % (95 % CI) 58.7 (52.7–64.5) 58.7 (49–67) 58.6 (53.6–63.4) 61 (43–77)
  Heterogeneity % (I2) 82.9   77.2