Table 2 Diagnostic accuracy results of overall NS1 Ag-based test kits
No. of study | Sensitivity % | Specificity % | Heterogeneity % | |
|---|---|---|---|---|
(95 % CI) | (95 % CI) | (I2) | ||
Overall | 18 | 66 (64.5–67.5) | 97.9 (97.3–100) | 82.6 |
Serological status | ||||
Primary | 9 | 88 (85.8–89.9) | 89.2 | |
Secondary | 10 | 60.8 (57.8–63.8) | 93.2 | |
DENV serotypes | ||||
DENV-1 | 10 | 79.5 (76.6–82.3) | 81 | |
DENV-2 | 11 | 62.7 (59.1–66.2) | 84.2 | |
DENV-3 | 10 | 73 (69.2–76.6) | 79.5 | |
DENV-4 | 5 | 46 (36–59.3) | 56 | |
Clinical severity | ||||
Dengue Fever | 5 | 70.3 (66.1–74.2) | 80.8 | |
Dengue Hemorrhagic Fever | 5 | 58.8 (54–63.4) | 71.6 | |
NS1 test assays | ||||
ELISA | 14 | 63.3 (61.5–65.1) | 94.9 | |
IC | 7 | 72.9 (70.1–75.5) | 90.8 | |