Table 2 Comparison of the results between the patient groups and the control group
From: The kynurenine pathway activities in a sub-Saharan HIV/AIDS population
|  | Total Patients | HAART (H) | HAART-Naïve (N) | Controls (C) | p-value (H vs. N) | p-value (H vs. C) | p-value (N vs. C) |
|---|---|---|---|---|---|---|---|
n | 105 | 75 | 30 | 60 | - | - | - |
Tryptophan (μmol/l) | 24.36 ± 4.14 | 25.13 ± 3.80 | 22.04 ± 4.32 | 43.57 ± 11.85 | 0.033 | <0.001 | <0.001 |
Kynurenine (μmol/l) | 3.21 ± 1.33 | 3.08 ± 1.28 | 3.58 ± 1.42 | 2.14 ± 0.45 | 0.144 | <0.005 | <0.001 |
Quinolinate (μmol/l) | 4.46 ± 2.32 | 4.03 ± 2.04 | 5.77 ± 2.65 | 0.25 ± 0.06 | 0.072 | <0.001 | <0.001 |
Nicotinamide (μmol/l) | 14.25 ± 9.47 | 13.31 ± 9.65 | 16.93 ± 8.61 | 12.92 ± 3.69 | 0.108 | 0.773 | 0.046 |
K/T ratio (μM/mM) | 136.03 ± 65.45 | 129.69 ± 65.36 | 158.07 ± 62.51 | 52.18 ± 16.95 | 0.095 | <0.001 | <0.001 |
Neopterin (nmol/l) | 45.57 ± 41.82 | 35.51 ± 35.70 | 66.63 ± 40.73 | 8.23 ± 5.71 | <0.001 | <0.001 | <0.001 |
IFN-γ (pg/ml) | 44.00 ± 22.55 | 41.43 ± 14.14 | 53.68 ± 34.39 | 24.85 ± 2.96 | 0.017 | <0.001 | <0.001 |
IL-6 (pg/ml) | 11.16 ± 14.95 | 9.56 ± 12.54 | 15.04 ± 19.34 | 0.69 ± 1.62 | 0.010 | 0.035 | 0.001 |
CD4 (cells/μl) | 259.92 ± 195.32 | 296.21 ± 195.50 | 170.05 ± 167.26 | - | 0.003 | - | - |