Table 2 Estimated outcomes of disease and mortality by vaccination strategy
Parameter | Age group (Years) | Â | |||||
|---|---|---|---|---|---|---|---|
|  | 0 - < 2 | 2 - 4 | 5 - 17 | 18 - 49 | 50 - 64 | 65+ | Total |
Non-pandemic year | Â | Â | Â | Â | Â | Â | Â |
Pneumococcal meningitis (Thousands) | Â | Â | Â | Â | Â | Â | Â |
  No Vaccination | 0.3 | 0.3 | 43.0 | 37.5 | 5.5 | 7.3 | 94.0 |
  Vaccination | 0.1 | 0.1 | 35.5 | 23.2 | 4.5 | 4.9 | 68.2 |
  Cases Avoided | 0.3 | 0.2 | 7.5 | 14.4 | 1.0 | 2.5 | 25.8 |
Pneumococcal bacteremia (Thousands) | Â | Â | Â | Â | Â | Â | Â |
  No Vaccination | 0.6 | 2.6 | 144.1 | 118.9 | 14.8 | 38.3 | 319.3 |
  Vaccination | 0.1 | 0.7 | 118.9 | 73.4 | 12.2 | 25.5 | 230.8 |
  Cases Avoided | 0.5 | 1.9 | 25.2 | 45.5 | 2.6 | 12.9 | 88.6 |
All-cause pneumonia (Thousands) | Â | Â | Â | Â | Â | Â | Â |
  No Vaccination | 568.6 | 2090.1 | 1959.5 | 1166.0 | 713.1 | 3936.9 | 10434.2 |
  Vaccination | 340.9 | 1531.3 | 1783.4 | 1026.1 | 648.9 | 3622.5 | 8953.1 |
  Cases Avoided | 227.6 | 558.8 | 176.2 | 139.8 | 64.2 | 314.4 | 1481.1 |
All-cause otitis media (Thousands) | Â | Â | Â | Â | Â | Â | Â |
  No Vaccination | 2972.6 | 12476.0 |  |  |  |  | 15448.6 |
  Vaccination | 2285.9 | 9704.6 |  |  |  |  | 11990.5 |
  Cases Avoided | 686.7 | 2771.4 |  |  |  |  | 3458.1 |
Deaths | Â | Â | Â | Â | Â | Â | Â |
  No Vaccination | 27393 | 8479 | 22921 | 85581 | 46750 | 410341 | 601465 |
  Vaccination | 16385 | 6156 | 20244 | 66622 | 42034 | 373311 | 524750 |
  Deaths Avoided | 11008 | 2323 | 2677 | 18959 | 4717 | 37030 | 76714 |
Life Years (Millions) | Â | Â | Â | Â | Â | Â | Â |
  No Vaccination | 1076.3 | 4194.8 | 19298.9 | 31151.6 | 3715.1 | 903.1 | 60339.7 |
  Vaccination | 1077.2 | 4195.0 | 19299.1 | 31152.4 | 3715.2 | 903.4 | 60342.2 |
  Life Years Saved | 0.9 | 0.2 | 0.2 | 0.8 | 0.1 | 0.3 | 2.5 |
QALYs (Millions) | Â | Â | Â | Â | Â | Â | Â |
  No Vaccination | 983.7 | 3829.8 | 17368.9 | 26696.9 | 2998.1 | 722.4 | 52599.8 |
  Vaccination | 984.6 | 3829.9 | 17369.1 | 26697.6 | 2998.2 | 722.7 | 52602.1 |
  QALYs Gained | 0.8 | 0.2 | 0.2 | 0.7 | 0.1 | 0.3 | 2.2 |
Pandemic year | Â | Â | Â | Â | Â | Â | Â |
Pneumococcal meningitis (Thousands) | Â | Â | Â | Â | Â | Â | Â |
  No Vaccination | 0.3 | 0.3 | 43.5 | 38.0 | 5.5 | 7.4 | 95.1 |
  Vaccination | 0.1 | 0.1 | 35.9 | 23.4 | 4.6 | 4.9 | 69.0 |
  Cases Avoided | 0.3 | 0.2 | 7.6 | 14.5 | 1.0 | 2.5 | 26.1 |
Pneumococcal bacteremia (Thousands) | Â | Â | Â | Â | Â | Â | Â |
  No Vaccination | 3.7 | 38.3 | 6967.3 | 3541.4 | 216.6 | 841.1 | 11608.4 |
  Vaccination | 0.7 | 9.8 | 5748.2 | 2186.7 | 179.0 | 558.9 | 8683.4 |
  Cases Avoided | 2.9 | 28.5 | 1219.1 | 1354.7 | 37.6 | 282.2 | 2925.0 |
All-cause pneumonia (Thousands) | Â | Â | Â | Â | Â | Â | Â |
  No Vaccination | 644.8 | 3096.9 | 3669.6 | 3332.9 | 855.9 | 3978.8 | 15578.8 |
  Vaccination | 386.7 | 2270.8 | 3371.1 | 2947.3 | 779.2 | 3671.2 | 13426.3 |
  Cases Avoided | 258.1 | 826.0 | 298.5 | 385.6 | 76.8 | 307.6 | 2152.5 |
All-cause otitis media (Thousands) | Â | Â | Â | Â | Â | Â | Â |
  No Vaccination | 2986.2 | 12348.1 |  |  |  |  | 15334.3 |
  Vaccination | 2302.9 | 9665.5 |  |  |  |  | 11968.4 |
  Cases Avoided | 683.3 | 2682.6 |  |  |  |  | 3365.9 |
Deaths | Â | Â | Â | Â | Â | Â | Â |
  No Vaccination | 314818 | 44700 | 779307 | 1170382 | 109165 | 758160 | 3176532 |
  Vaccination | 187101 | 28401 | 652085 | 869387 | 95870 | 636163 | 2469006 |
  Deaths Avoided | 127717 | 16300 | 127222 | 300995 | 13295 | 121997 | 707526 |
Life Years (Millions) | Â | Â | Â | Â | Â | Â | Â |
  No Vaccination | 1053.2 | 4192.0 | 19249.4 | 31104.0 | 3713.7 | 900.1 | 60212.2 |
  Vaccination | 1063.5 | 4193.2 | 19257.7 | 31117.2 | 3714.0 | 901.1 | 60246.7 |
  Life Years Saved | 10.3 | 1.3 | 8.3 | 13.2 | 0.3 | 1.0 | 34.4 |
QALYs (Millions) | Â | Â | Â | Â | Â | Â | Â |
  No Vaccination | 962.6 | 3827.2 | 17324.3 | 26656.0 | 2997.0 | 720.0 | 52487.1 |
  Vaccination | 972.0 | 3828.4 | 17331.8 | 26667.4 | 2997.2 | 720.9 | 52517.6 |
  QALYs Gained | 9.4 | 1.2 | 7.5 | 11.3 | 0.2 | 0.8 | 30.5 |