The health and economic impact of vaccination with 7-valent pneumococcal vaccine (PCV7) during an annual influenza epidemic and influenza pandemic in China

Table 1 Input parameters

Parameter	Age group (Years)
	0 - < 2	2 - 4	5 - 17	18 - 49	50 - 64	65+
Annual Incidence Rates per 100,000
Pneumococcal meningitis	2.5	0.6	14.6	5.2	3.4	6.9
Pneumococcal bacteremia	4.8	4.7	48.8	16.7	9.2	36.0
All-cause inpatient pneumonia	4239	3830	664	164	443	3700
All-cause otitis media (per person)	0.22	0.23
Percent of Meningitis that results in deafness	13 %	13 %	6 %	13 %	13 %	13 %
Percent of Meningitis that results in disability	7 %	7 %	5 %	7 %	7 %	7 %
Case-fatality rates
Pneumococcal meningitis	.083	.083	.088	.472	.636	.768
Pneumococcal bacteremia	.115	.036	.024	.130	.177	.288
All-cause inpatient pneumonia	.048	.004	.008	.045	.057	.100
Direct Efficacy of Vaccine
Pneumococcal meningitis	73.5 %	67.1 %
Pneumococcal bacteremia	73.5 %	67.1 %
All-cause inpatient pneumonia	16.9 %	22.9 %
All-cause otitis media	6.4 %	5.8 %
Indirect (herd) Effect of Vaccine
Pneumococcal meningitis	46.8 %	40.3 %	17.5 %	38.3 %	17.4 %	33.6 %
Pneumococcal bacteremia	46.8 %	40.3 %	17.5 %	38.3 %	17.4 %	33.6 %
All-cause inpatient pneumonia	30.0 %	9.0 %	9.0 %	12.0 %	9.0 %	8.0 %
All-cause otitis media	20.1 %	19.0 %
Cost (¥) per Case of Pneumococcal Disease
Pneumococcal meningitis	24347	14805	24660	21825	21331	34495
Pneumococcal bacteremia	24347	14805	24660	21825	21331	34495
All-cause inpatient pneumonia	4416	2466	2867	8237	10517	14493
All-cause otitis media	148	136

ISSN: 1471-2334