Combining standard clinical methods with PCR showed improved diagnosis of invasive pulmonary aspergillosis in patients with hematological malignancies and prolonged neutropenia

Table 1 Results of combined biomarker testing of patients with febrile neutropenia^a at the University Hospitals of Debrecen^b

Patient ID	Underlying condition	Sex, age (yr)	EORTC/MSG classification	No. of specimens per episode	No. of GM specimens		No. of PCR specimens		No. of PCR runs
Patient ID	Underlying condition	Sex, age (yr)	EORTC/MSG classification	No. of specimens per episode	Positive	Negative	Positive	Negative	Positive	Negative
1	PTCL	M, 18	possible	8	0	4	1	3	3	9
2	NHL	M, 15	possible	14	0	7	2	5	2	19
3	OM	M, 16	possible	16	0	8	1	7	3	21
4	AML	M, 26	proven	18	0	7	10	1	18	15
5	OM	F, 53	possible	6	1	2	0	3	0	9
6	AML	M, 55	possible	4	0	2	1	1	1	5
7	AML	M, 52	proven	4	2	0	2	0	3	3
8	AML	F, 28	proven	6	1	2	3	0	3	4
9	MM	M, 70	possible	2	0	1	0	1	0	3
10	ALL	F, 27	probable	8	2	0	6	0	13	1
11	OM	M, 57	possible	2	0	1	0	1	0	3
12	OM	F, 66	possible	6	0	3	0	3	0	9
13	AML	F, 55	probable	8	2	2	4	0	8	4
14	AML	F, 46	possible	2	0	1	0	1	0	3
15	MM	F, 44	possible	2	0	1	0	1	0	3
16	OM	M, 56	proven	6	0	3	1	2	1	8
17	HL	F, 26	possible	4	0	2	0	2	0	6
18	AML	F, 50	possible	2	0	1	1	0	3	0
19	ALL	M, 14	possible	4	0	2	0	2	0	6
20	AML	F, 45	possible	6	0	3	0	3	0	9
21	OM	M, 17	possible	6	0	3	0	3	0	9
22	OM	F, 19	possible	8	0	4	3	1	3	9
23	NHL	M, 57	possible	2	0	1	0	1	0	3
24	AML	M, 36	possible	6	1	2	0	3	0	9
25	NHL	M, 75	proven	6	2	1	1	2	1	8
26	AML	M, 49	possible	4	0	2	0	2	0	6
27	OM	M, 16	possible	2	0	1	0	1	0	3
			Total:	162	77		85		249

^aNeutrophil count < 0,5 × 10⁹ cells/L; ^bUniversity of Debrecen, Institute of Internal Medicine; AML Acute Myeloid Leukemia, ALL Acute Lymphoblastic Leukemia, MM Myeloma Multiplex, NHL Non-Hodgkin Lymphoma, PTCL Peripheral T-cell Lymphoma, OMs other malignancies, P present, A absent, NP not performed, CT thoracic computed tomography, BAL bronchoscopy with lavage

ISSN: 1471-2334