Clinical evaluation of commercial nucleic acid amplification tests in patients with suspected sepsis

BMC Infectious Diseases

Table 2 Diagnostic performance of blood culture, multiplex PCR, and microarray ^a

	Sensitivity	Specificity	PPV	NPV	Accuracy
	(95% CI)	(95% CI)	(95% CI)	(95% CI)	(95% CI)
Blood culture	72% (61–84)	99% (99–100)	98% (93–100)	94% (92–97)	95% (92–97)
Multiplex PCR	64% (51–76)	96% (93–98)	73% (60–85)	94% (91–96)	91% (88–94)
Microarray	62% (49–75)	99% (97–100)	86% (75–97)	95% (92–97)	94% (91–96)

NPV negative predictive value; PPV positive predictive value.
^aFor each method, all episodes were classified according following criteria: i) true positive – episode positive for at least one clinically relevant finding; ii) false positive - episode positive only for finding(s) of unknown significance; iii) false negative - episode negative with the method, but positive for at least one clinically relevant finding detected by another method; iv) true negative - episode negative with the method and for which no clinically relevant findings were detected by any method.

ISSN: 1471-2334