Table 1 Baseline characteristics for participants vaccinated before or after HIV diagnosis
Vaccinated Before HIV Diagnosis | Vaccinated After HIV Diagnosis | |||||||
|---|---|---|---|---|---|---|---|---|
Characteristic | Total | Vaccine responder | Vaccine non-responder | P value | Total | Vaccine Responder | Vaccine non-responder | P value |
Number, n | 307 | 288 (94) | 19 (6) | -- | 169 | 74 (44) | 95 (56) | -- |
Age at HIV diagnosis (years) | 29 (25-36) | 29 (25-36) | 34 (26-41) | 0.170 | 28 (24-34) | 27 (24-32) | 29 (25-34) | 0.349 |
Gender, Male | 291 (95) | 274 (95) | 17 (89) | 0.260 | 148 (94) | 63 (85) | 85 (89) | 0.540 |
Ethnicity | 0.085 | 0.142 | ||||||
Caucasian | 116 (38) | 104 (36) | 12 (63) | 70 (41) | 28 (38) | 42 (44) | ||
African American | 134 (44) | 129 (45) | 5 (26) | 69 (41) | 28 (38) | 41 (43) | ||
Hispanic/Other | 57 (18) | 55 (19) | 2 (11) | 30 (18) | 18 (24) | 12 (13) | ||
Median CD4 Count (cells/mm3) at HIV diagnosis | 436 (307-570) | 438 (312-570) | 372 (282-561) | 0.335 | 526 (405-711) | 543 (422-724) | 517 (382-676) | 0.129 |
Median VL at HIV diagnosis (log10 copies/mL) | 4.5 (3.9-5.0) | 4.5 (3.9-5.0) | 4.7 (4.2-5.1) | 0.853 | 4.2 (3.5-4.4) | 4.2 (3.4-4.6) | 4.2 (3.5-4.4) | 0.888 |
Number of HBV vaccine doses | 3 (2-3) | 3 (1-3) | 3 (3-3) | 0.101 | 3 (1-3) | 2 (1-3) | 3 (2-3) | 0.585 |
Median time from last vaccination to anti-HBs determination (months) | 18.1 (6.1-57) | 26 (7.4-67) | 6.8 (4.3-15) | 0.222 | 5.2 (2.8-6.8) | 5.5 (2.8-7.1) | 4.9 (2.7-6.4) | 0.340 |
Median CD4 Count at last HBV vaccination (cells/mm3) | -- | -- | -- | -- | 489 (353-628) | 481 (331-621) | 510 (394-629) | 0.669 |
Median VL at last HBV vaccination (log10 copies/mL) | -- | -- | -- | -- | 4.1 (3.6-4.6) | 4.1 (3.7-4.6) | 4.1 (3.3-4.4) | 0.274 |
Year of cART initiation | 2008 (2003-2010) | 2008 (2003-2010) | 2003 (2000-2008) | 0.051 | 1998 (1997-2006) | 2004 (1997-2009) | 1998 (1997- 2004) | 0.001 |
Median time from HIV diagnosis to cART initiation (months) | 7.8 (2.0-27.0) | 8 (2.1-29.0) | 2.1 (1.3-11.0) | 0.273 | 57 (29-91) | 51 (29-93) | 59 (29-90) | 0.603 |
Median CD4 Count (cells/mm3) at cART initiation | 356 (270-445) | 360 (270-448) | 298 (234-394) | 0.398 | 379 (249-473) | 390 (277-492) | 377 (215-460) | 0.137 |
Median VL at cART initiation (log10 copies/mL) | 4.5 (4.0-5.0) | 4.5 (3.9-5.0) | 4.4 (4.3-5.0) | 0.619 | 4.4 (3.6-4.8) | 4.4 (3.9-4.7) | 4.4 (3.5-4.8) | 0.864 |
Initial cART regimen | 0.669 | 0.612 | ||||||
NNRTI | 193 (63) | 180 (62) | 13 (68) | 67 (40) | 31 (42) | 36 (38) | ||
Boosted PI | 34 (11) | 31 (11) | 3 (16) | 18 (11) | 5 (7) | 13 (14) | ||
Unboosted PI | 52 (17) | 49 (17) | 3 (16) | 67 (40) | 29 (39) | 38 (40) | ||
Triple NRTI | 26 (8) | 26 (9) | 0 (0) | 7 (4) | 4 (5) | 5 (5) | ||
Other | 2 (1) | 2 (1) | 0 (0) | 10 (6) | 5 (7) | 0 (0) | ||
Hepatitis C diagnosis before cART initiation | 9 (3) | 9 (3) | 0 (0) | 1.000 | 8 (5) | 3 (4) | 5 (5) | 1.000 |