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Table 1 Baseline characteristics for participants vaccinated before or after HIV diagnosis

From: Association between hepatitis B vaccine antibody response and CD4 reconstitution after initiation of combination antiretroviral therapy in HIV-infected persons

  Vaccinated Before HIV Diagnosis Vaccinated After HIV Diagnosis
Characteristic Total Vaccine responder Vaccine non-responder P value Total Vaccine Responder Vaccine non-responder P value
Number, n 307 288 (94) 19 (6) -- 169 74 (44) 95 (56) --
Age at HIV diagnosis (years) 29 (25-36) 29 (25-36) 34 (26-41) 0.170 28 (24-34) 27 (24-32) 29 (25-34) 0.349
Gender, Male 291 (95) 274 (95) 17 (89) 0.260 148 (94) 63 (85) 85 (89) 0.540
Ethnicity     0.085     0.142
Caucasian 116 (38) 104 (36) 12 (63) 70 (41) 28 (38) 42 (44)
African American 134 (44) 129 (45) 5 (26) 69 (41) 28 (38) 41 (43)
Hispanic/Other 57 (18) 55 (19) 2 (11) 30 (18) 18 (24) 12 (13)
Median CD4 Count (cells/mm3) at HIV diagnosis 436 (307-570) 438 (312-570) 372 (282-561) 0.335 526 (405-711) 543 (422-724) 517 (382-676) 0.129
Median VL at HIV diagnosis (log10 copies/mL) 4.5 (3.9-5.0) 4.5 (3.9-5.0) 4.7 (4.2-5.1) 0.853 4.2 (3.5-4.4) 4.2 (3.4-4.6) 4.2 (3.5-4.4) 0.888
Number of HBV vaccine doses 3 (2-3) 3 (1-3) 3 (3-3) 0.101 3 (1-3) 2 (1-3) 3 (2-3) 0.585
Median time from last vaccination to anti-HBs determination (months) 18.1 (6.1-57) 26 (7.4-67) 6.8 (4.3-15) 0.222 5.2 (2.8-6.8) 5.5 (2.8-7.1) 4.9 (2.7-6.4) 0.340
Median CD4 Count at last HBV vaccination (cells/mm3) -- -- -- -- 489 (353-628) 481 (331-621) 510 (394-629) 0.669
Median VL at last HBV vaccination (log10 copies/mL) -- -- -- -- 4.1 (3.6-4.6) 4.1 (3.7-4.6) 4.1 (3.3-4.4) 0.274
Year of cART initiation 2008 (2003-2010) 2008 (2003-2010) 2003 (2000-2008) 0.051 1998 (1997-2006) 2004 (1997-2009) 1998 (1997- 2004) 0.001
Median time from HIV diagnosis to cART initiation (months) 7.8 (2.0-27.0) 8 (2.1-29.0) 2.1 (1.3-11.0) 0.273 57 (29-91) 51 (29-93) 59 (29-90) 0.603
Median CD4 Count (cells/mm3) at cART initiation 356 (270-445) 360 (270-448) 298 (234-394) 0.398 379 (249-473) 390 (277-492) 377 (215-460) 0.137
Median VL at cART initiation (log10 copies/mL) 4.5 (4.0-5.0) 4.5 (3.9-5.0) 4.4 (4.3-5.0) 0.619 4.4 (3.6-4.8) 4.4 (3.9-4.7) 4.4 (3.5-4.8) 0.864
Initial cART regimen     0.669     0.612
 NNRTI 193 (63) 180 (62) 13 (68)   67 (40) 31 (42) 36 (38)
 Boosted PI 34 (11) 31 (11) 3 (16)   18 (11) 5 (7) 13 (14)
 Unboosted PI 52 (17) 49 (17) 3 (16)   67 (40) 29 (39) 38 (40)
 Triple NRTI 26 (8) 26 (9) 0 (0)   7 (4) 4 (5) 5 (5)
 Other 2 (1) 2 (1) 0 (0)   10 (6) 5 (7) 0 (0)
Hepatitis C diagnosis before cART initiation 9 (3) 9 (3) 0 (0) 1.000 8 (5) 3 (4) 5 (5) 1.000
  1. HBV, hepatitis B virus; responder, antibody to HBV surface antigen (anti-HBs) ≥10 IU/L; non-responder, anti-HBs <10 IU/L; VL, viral load; cART, combination antiretroviral therapy; NNRTI, non-nucleoside reverse transcriptase inhibitor; PI, protease inhibitor; NRTI, nucleoside reverse transcriptase inhibitor.
  2. Data are number (%) or median (interquartile range) unless otherwise specified.