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Table 4 Syndromic and definitive diagnoses γ according to WHO stages and ANRS degrees of severity, in HIV-infected adults receiving antiretroviral treatment, IeDEA West Africa, December 2009 to December 2011

From: Severe morbidity after antiretroviral (ART) initiation: active surveillance in HIV care programs, the IeDEA West Africa collaboration

Diagnoses, number Total   WHO classification ANRS degrees of severity Hospitalisation* Death**
  N = 1675 (%) Stage 3 Stage 4 Degree 3 Degree 4   
Infectious events         
Parasitic events         
   Malaria 359 (24.8)    99 12 127  
   Cerebral toxoplasmosis 24 (1.7) 0 24    15 3
   Other parasitic events 9 (0.6)   3 1   2  
Bacterial events         
   Pneumonia 194 (13.4) 194     79 2
   Tuberculosis 111 (7.7) 45 66    43 4
   ENT infection 26 (1.8)    2   3  
   Severe bacterial infection 17 (1.2) 17     7 1
Other eventsβ 12 (0.8)    2 2 3  
Mycotic events         
   Oral candidiasis 138 (9.5) 133     8  
   Other mycoses£ 25 (1.7)   11    1  
Infectious diarrhoea 121 (8.4)    45 12 75  
Skin infections 16 (1.1)    1   5  
Viral infections π 35 (2.4)   25 1   15 1
Other infectious events α 27 (1,9)    5 4 10  
Non infectious diagnosis         
   Peripheral neuropathy*** 52 (3.6)    39 5 5  
   Toxiderma 19 (1.3)    6 7 11  
   Tumors 17 (1.2)   11   1 9  
   Other non infectious diagnosesΨ 46 (3.2)    8 17 13 1
Non specific events         
   Anemia 164 (11.3)    57 82 84 3
   Fever 49 (3.4)   4 9 4 10 1
   Diarrhoea 25 (1.7)   5 11 1 18 2
   Other general signsθ 57 (3.9)    23 16 41 2
   Other non specificф 31 (2.1)    7 5 32 3
Death 101        
  1. ENT = Ear Nose Throat.
  2. γ Several diagnoses for a same event.
  3. *Number of events with at least one day in day care.
  4. ** Number of death occurring after the event.
  5. *** including 37 neuropathies secondary to ART initiation.
  6. (%) Percentage calculated based on the number of events.
  7. including 54 anaemia secondary to a treatment.
  8. 6 ameibiasis, 2 pneumocystoses, 1 microsporidia.
  9. β9 urinary infections, 2 appendicites, 1 cholecystitis.
  10. £11 vaginal candidosis, 10 oesophagal candidosis, 3 digestive candidosis, 1 cryptococcal.
  11. π21 HIV-related cachexia syndrome, 8 herpes zoster, 4 HIV-related encephalopathies, 2 herpes.
  12. Tumors: 9 kaposi, 4 benign tumors, 2 unkown evolutive tumors, 1 cervical cancer, 1 Non-Hodgkin malignant Lymphoma.
  13. Ψ Cardio-vascular (6 arterial hypertension, 4 peripheral veins, 2 stroke), Renal (6 nephropathy, 6 renal failure), metabolic (5 abnormal fat distribution, 1 lactic acidosis, 1 diabetes), Genito-obstetric (two abortions, two other), Gastrointestinal (3 gastric or duodenal ulcers, 1 chronic pancreatitis, 7 other.
  14. α7 genital infections, 6 osteoarticular infections, 6 broncho-pneumopathy, 5 meningitis, 2 stomatitis, 1 hepatitis.
  15. θ19 asthenia, 21 dehydration, 17 under-nutrition.
  16. Ф1 digestive disorders, 6 hemiplegia/tetraplegia, 6 psychiatric signs, 5 neutropenia, 2 liver signs, 11 other signs.