Severe morbidity after antiretroviral (ART) initiation: active surveillance in HIV care programs, the IeDEA West Africa collaboration

Table 4 Syndromic and definitive diagnoses ^γ according to WHO stages and ANRS degrees of severity, in HIV-infected adults receiving antiretroviral treatment, IeDEA West Africa, December 2009 to December 2011

Diagnoses, number	Total		WHO classification		ANRS degrees of severity		Hospitalisation*	Death**
	N = 1675	(%)	Stage 3	Stage 4	Degree 3	Degree 4
Infectious events
Parasitic events
Malaria	359	(24.8)			99	12	127
Cerebral toxoplasmosis	24	(1.7)	0	24			15	3
Other parasitic events^‡	9	(0.6)		3	1		2
Bacterial events
Pneumonia	194	(13.4)	194				79	2
Tuberculosis	111	(7.7)	45	66			43	4
ENT infection	26	(1.8)			2		3
Severe bacterial infection	17	(1.2)	17				7	1
Other events^β	12	(0.8)			2	2	3
Mycotic events
Oral candidiasis	138	(9.5)	133				8
Other mycoses^£	25	(1.7)		11			1
Infectious diarrhoea	121	(8.4)			45	12	75
Skin infections	16	(1.1)			1		5
Viral infections ^π	35	(2.4)		25	1		15	1
Other infectious events ^α	27	(1,9)			5	4	10
Non infectious diagnosis
Peripheral neuropathy***	52	(3.6)			39	5	5
Toxiderma	19	(1.3)			6	7	11
Tumors	17	(1.2)		11		1	9
Other non infectious diagnoses^Ψ	46	(3.2)			8	17	13	1
Non specific events
Anemia^†	164	(11.3)			57	82	84	3
Fever	49	(3.4)		4	9	4	10	1
Diarrhoea	25	(1.7)		5	11	1	18	2
Other general signs^θ	57	(3.9)			23	16	41	2
Other non specific^ф	31	(2.1)			7	5	32	3
Death	101

ENT = Ear Nose Throat.
γ Several diagnoses for a same event.
*Number of events with at least one day in day care.
** Number of death occurring after the event.
*** including 37 neuropathies secondary to ART initiation.
(%) Percentage calculated based on the number of events.
^†including 54 anaemia secondary to a treatment.
^‡6 ameibiasis, 2 pneumocystoses, 1 microsporidia.
^β9 urinary infections, 2 appendicites, 1 cholecystitis.
^£11 vaginal candidosis, 10 oesophagal candidosis, 3 digestive candidosis, 1 cryptococcal.
^π21 HIV-related cachexia syndrome, 8 herpes zoster, 4 HIV-related encephalopathies, 2 herpes.
Tumors: 9 kaposi, 4 benign tumors, 2 unkown evolutive tumors, 1 cervical cancer, 1 Non-Hodgkin malignant Lymphoma.
^Ψ Cardio-vascular (6 arterial hypertension, 4 peripheral veins, 2 stroke), Renal (6 nephropathy, 6 renal failure), metabolic (5 abnormal fat distribution, 1 lactic acidosis, 1 diabetes), Genito-obstetric (two abortions, two other), Gastrointestinal (3 gastric or duodenal ulcers, 1 chronic pancreatitis, 7 other.
^α7 genital infections, 6 osteoarticular infections, 6 broncho-pneumopathy, 5 meningitis, 2 stomatitis, 1 hepatitis.
^θ19 asthenia, 21 dehydration, 17 under-nutrition.
^Ф1 digestive disorders, 6 hemiplegia/tetraplegia, 6 psychiatric signs, 5 neutropenia, 2 liver signs, 11 other signs.

ISSN: 1471-2334