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Table 3 Association between comorbidity and death in vertically HIV-infected children and adolescents presented in order of statistical significance according to the chi-square test

From: Mortality in children and adolescents vertically infected by HIV receiving care at a referral hospital in Vitoria, Brazil

  Current Status  
Comorbidity Alive Dead p-value
  N % N %
P. jiroveci Pneumonia 21 14 13 54 0.000
Thrombocytopenia 15 10 9 36 0.002
Severe recurrent bacterial infections 63 43 19 76 0.002
Candidiasis – any type 45 30 15 60 0.004
Chronic anemia 94 63 23 92 0.004
HIV/Hepatitis co-infection 22 15 10 40 0.009
Wasting syndrome 29 19 10 40 0.023
Extrapulmonary cryptococcosis 1 1 2 8 0.054
Kidney disorders 1 1 2 8 0.056
Tuberculosis 17 11 7 27 0.056
Lymphadenopathy > 0.5 cm at more than two sites 106 71 13 52 0.057
First episode of pneumonia, bacteremia or sepsis 91 61 20 80 0.074
Prolonged diarrhea or gastroenteritis 57 38 14 56 0.095
HIV encephalopathy 19 13 6 24 0.138
Cerebral toxoplasmosis 1 1 1 4 0.148
Non-Hodgkin’s lymphoma 1 1 1 4 0.150
HIV-associated myocarditis 3 2 2 8 0.152
Splenomegaly 92 62 19 76 0.170
Persistent fever 46 31 11 44 0.196
Chronic parotitis 22 15 1 4 0.205
Lymphocytic interstitial pneumonia 31 21 3 12 0.304
Congenital syphilis 5 3 0 0 0.351
Any helminth or protozoan infection 14 9 1 4 0.374
Mucocutaneous herpes simplex 4 3 0 0 0.404
Dyslipidemia 11 7 1 4 0.532
Isosporiasis 2 1 0 0 0.556
Hepatomegaly 120 81 22 88 0.577
Dermatitis 63 42 12 48 0.593
Urinary infection 30 20 6 24 0.659
Progressive multifocal leukoencephalopathy 1 1 0 0 0.681
Disseminated mycobacteriosis 1 1 0 0 0.681
Acute otitis media or recurrent sinusitis 84 56 13 52 0.709
Cytomegalovirus infection 14 9 3 12 0.725
Pancreatitis associated with HIV infection 8 5 1 4 0.775
Congenital or acquired toxoplasmosis 10 7 2 8 0.902
Varicella or Herpes zoster 43 29 7 28 0.930
Gingivostomatitis or recurrent herpes 5 3 0 0 1
Cryptosporidiosis 1 1 0 0 1
  1. Infectious Diseases and AIDS Pediatric Care Clinic of the State Pediatric Hospital between 2001 and 2011 (n = 177), Vitoria, Brazil.