Table 3 Association between comorbidity and death in vertically HIV-infected children and adolescents presented in order of statistical significance according to the chi-square test

P. jiroveci Pneumonia

21

14

13

54

0.000

Thrombocytopenia

15

10

9

36

0.002

Severe recurrent bacterial infections

63

43

19

76

0.002

Candidiasis – any type

45

30

15

60

0.004

Chronic anemia

94

63

23

92

0.004

HIV/Hepatitis co-infection

22

15

10

40

0.009

Wasting syndrome

29

19

10

40

0.023

Extrapulmonary cryptococcosis

1

1

2

8

0.054

Kidney disorders

1

1

2

8

0.056

Tuberculosis

17

11

7

27

0.056

Lymphadenopathy > 0.5 cm at more than two sites

106

71

13

52

0.057

First episode of pneumonia, bacteremia or sepsis

91

61

20

80

0.074

Prolonged diarrhea or gastroenteritis

57

38

14

56

0.095

HIV encephalopathy

19

13

6

24

0.138

Cerebral toxoplasmosis

1

1

1

4

0.148

Non-Hodgkin’s lymphoma

1

1

1

4

0.150

HIV-associated myocarditis

3

2

2

8

0.152

Splenomegaly

92

62

19

76

0.170

Persistent fever

46

31

11

44

0.196

Chronic parotitis

22

15

1

4

0.205

Lymphocytic interstitial pneumonia

31

21

3

12

0.304

Congenital syphilis

5

3

0

0

0.351

Any helminth or protozoan infection

14

9

1

4

0.374

Mucocutaneous herpes simplex

4

3

0

0

0.404

Dyslipidemia

11

7

1

4

0.532

Isosporiasis

2

1

0

0

0.556

Hepatomegaly

120

81

22

88

0.577

Dermatitis

63

42

12

48

0.593

Urinary infection

30

20

6

24

0.659

Progressive multifocal leukoencephalopathy

1

1

0

0

0.681

Disseminated mycobacteriosis

1

1

0

0

0.681

Acute otitis media or recurrent sinusitis

84

56

13

52

0.709

Cytomegalovirus infection

14

9

3

12

0.725

Pancreatitis associated with HIV infection

8

5

1

4

0.775

Congenital or acquired toxoplasmosis

10

7

2

8

0.902

Varicella or Herpes zoster

43

29

7

28

0.930

Gingivostomatitis or recurrent herpes

5

3

0

0

1

Cryptosporidiosis

1

1

0

0

1