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Table 3 Immunologic response to cART according to mode of cART initiation (cART initiation during CHI versus cART resumption) from linear mixed-effects models with 3 slopes

From: Does transient cART started during primary HIV infection undermine the long-term immunologic and virologic response on cART resumption?

Parameter

Univariate estimate

SE

Pvalue

Adjusted estimateb

SE

Pvalue

Intercept √CD4 cART (reference)

19.085

0.235

<0.0001

   

cART resumption vs Initiation during CHIa

1.012

0.482

0.04

−0.067

0.347

0.8

Slope 1 (0-3mo) √CD4/month (ref)

0.995

0.058

<0.0001

   

cART resumption vs initiation during CHIa

0.118

0.126

0.4

0.063

0.129

0.5

Slope 2 (3–12 mo) √CD4/month (ref)

0.222

0.018

<0.0001

   

cART resumption vs initiation during CHIa

−0.071

0.036

0.06

−0.056

0.038

0.1

Slope 3 > 12 mo √CD4/month (ref.)

0.070

0.007

<0.0001

   

cART resumption vs initiation during CHIa

−0.029

0.011

0.01

−0.024

0.012

0.04

  1. aDifference between cART resumption and cART initiation during CHI (reference).
  2. bAdjusted in multivariate analysis, for age (≥40 versus <40 years), calendar period, HIV-RNA level (≥5 log versus <5), active smoking at cART initiation/resumption, HIV transmission group (homosexual men, heterosexual men, women), geographic origin, time since HIV infection, HIV subtype (B versus non B), baseline genotypic resistance, and CD4 cell count at PHI diagnosis.