Figure 3From: Mass campaigns with antimalarial drugs: a modelling comparison of artemether-lumefantrine and DHA-piperaquine with and without primaquine as tools for malaria control and eliminationCampaign outcome depends on timing, diagnostic sensitivity, coverage, and compliance. (A) Asexual parasite prevalence (top) and daily EIR (bottom) of a semi-immune population of 1000 people with no intervention (black), multi-round MDA with AL (red), and multi-round MDA with DP (blue). Solid lines: 3-round campaigns. Dashed lines: 2-round campaigns. MDAs were simulated with 100% coverage and 100% compliance. Annual EIR was 50, and infected individuals were those with ≥10 asexual parasites/μL. DP’s long prophylactic tail better protects against reinfection after campaign. (B) Prevalence 1 month after campaign for 3-round and 2-round MDA campaigns with AL or DP. MDAs were simulated with 70% coverage and 100% compliance; annual EIR was 50. Error bars: 95% confidence interval. (C) Prevalence 1 month after 3-round MSAT campaigns with varying sensitivity of MSAT diagnostic. Coverage and compliance were 100%; annual EIR was 50. Shaded areas: 95% confidence interval. (D) Prevalence 1 month after 3-round MDA campaigns with varying coverage and 100% compliance. Annual EIR was 50. Shaded areas: 95% confidence interval. (E) Prevalence 1 month after 3-round MDA campaigns with varying compliance and 100% coverage. All covered individuals take the first dose of AL or DP; subsequent doses are taken with probability equal to the compliance. Annual EIR was 50. Shaded areas: 95% confidence interval.Back to article page