No. of HPV types*
|
Time§
|
Pre-specified true composite prevalence (SD)
|
Composite prevalence estimate (SD)
|
Est. to true ratio
|
Composite prevalence estimate (SD)
|
Est. to true ratio
|
Composite prevalence estimate (SD)
|
Est. to true ratio
|
Composite prevalence estimate (SD)
|
Est. to true ratio
|
---|
a: Sensitivity ≤ Specificity
|
| | |
Sen.= 0.95
| |
Sen. = 0.90
| |
Sen. = 0.85
| |
Sen. = 0.80
| |
Spe.= 0.95
|
Spe. = 0.95
|
Spe. = 0.95
|
Spe. = 0.95
|
2
|
Baseline
|
0.064 (0.004)
|
0.151 (0.006)
|
2.359
|
0.148 (0.005)
|
2.313
|
0.146 (0.006)
|
2.281
|
0.143 (0.005)
|
2.234
|
|
Reduced
|
0.032 (0.003)
|
0.125 (0.005)
|
3.906
|
0.123 (0.005)
|
3.843
|
0.121 (0.005)
|
3.781
|
0.120 (0.005)
|
3.750
|
|
% red.
|
50
|
17.2
| |
16.9
| |
17.1
| |
13.9
| |
4
|
Baseline
|
0.120 (0.005)
|
0.275 (0.007)
|
2.292
|
0.269 (0.007)
|
2.242
|
0.264 (0.007)
|
2.200
|
0.260 (0.007)
|
2.167
|
|
Reduced
|
0.062 (0.004)
|
0.229 (0.007)
|
3.694
|
0.227 (0.006)
|
3.661
|
0.224 (0.007)
|
3.613
|
0.222 (0.006)
|
3.581
|
|
% red.
|
48
|
16.7
| |
15.6
| |
15.2
| |
14.6
| |
14
|
Baseline
|
0.282 (0.007)
|
0.616 (0.007)
|
2.184
|
0.609 (0.008)
|
2.160
|
0.603 (0.008)
|
2.138
|
0.596 (0.008)
|
2.113
|
|
Reduced
|
0.259 (0.007)
|
0.604 (0.008)
|
2.332
|
0.599 (0.008)
|
2.313
|
0.593 (0.008)
|
2.290
|
0.587 (0.008)
|
2.266
|
|
% red.
|
8.2
|
1.9
| |
1.6
| |
1.7
| |
1.5
| |
37
|
Baseline
|
0.617 (0.008)
|
0.904 (0.004)
|
1.465
|
0.900 (0.005)
|
1.459
|
0.895 (0.005)
|
1.451
|
0.891 (0.005)
|
1.444
|
|
Reduced
|
0.596 (0.008)
|
0.899 (0.005)
|
1.508
|
0.895 (0.005)
|
1.502
|
0.891 (0.005)
|
1.495
|
0.887 (0.005)
|
1.488
|
|
% red.
|
3.4
|
0.5
| |
0.6
| |
0.4
| |
0.4
| |
b: Sensitivity ≥ Specificity
|
| | |
Sen. = 0.95
| |
Sen. = 0.95
| |
Sen. = 0.95
| |
Sen. = 0.95
| |
Spe. = 0.95
|
Spe. = 0.90
|
Spe. = 0.85
|
Spe. = 0.80
|
2
|
Baseline
|
0.064 (0.004)
|
0.151 (0.006)
|
2.359
|
0.237 (0.007)
|
3.703
|
0.318 (0.007)
|
4.969
|
0.394 (0.008)
|
6.156
|
|
Reduced
|
0.032 (0.003)
|
0.125 (0.005)
|
3.906
|
0.213 (0.006)
|
6.656
|
0.297 (0.007)
|
9.281
|
0.374 (0.008)
|
11.688
|
|
% red.
|
50
|
17.2
| |
10.1
| |
6.6
| |
5.1
| |
4
|
Baseline
|
0.120 (0.005)
|
0.275 (0.007)
|
2.292
|
0.409 (0.008)
|
3.408
|
0.525 (0.008)
|
4.375
|
0.621 (0.008)
|
5.175
|
|
Reduced
|
0.062 (0.004)
|
0.229 (0.007)
|
3.694
|
0.374 (0.008)
|
6.033
|
0.496 (0.008)
|
8.000
|
0.598 (0.008)
|
9.645
|
|
% red.
|
48
|
16.7
| |
8.6
| |
5.5
| |
3.7
| |
14
|
Baseline
|
0.282 (0.007)
|
0.616 (0.008)
|
2.184
|
0.797 (0.006)
|
2.826
|
0.895 (0.005)
|
3.174
|
0.947 (0.004)
|
3.358
|
|
Reduced
|
0.259 (0.006)
|
0.604 (0.008)
|
2.332
|
0.792 (0.006)
|
3.058
|
0.892 (0.005)
|
3.444
|
0.945 (0.004)
|
3.649
|
|
% red.
|
8.2
|
1.9
| |
0.6
| |
0.3
| |
0.2
| |
37
|
Baseline
|
0.617 (0.008)
|
0.904 (0.004)
|
1.465
|
0.975 (0.002)
|
1.580
|
0.993 (0.001)
|
1.609
|
0.998 (0.007)
|
1.515
|
|
Reduced
|
0.596 (0.008)
|
0.899 (0.005)
|
1.508
|
0.974 (0.003)
|
1.634
|
0.993 (0.001)
|
1.666
|
0.998 (0.007)
|
1.674
|
|
% red.
|
3.4
|
0.5
| |
0.1
| |
0
| |
0
| |
- *2: high-risk vaccine types (HPV 16, 18); 4: vaccine types (HPV 6, 11, 16, 18); 14: high-risk types (HPV 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68); 37: HPV types (HPV 6, 11, 16, 18, 26, 31, 33, 35, 39, 40, 42, 45, 51, 52, 53, 54, 55, 56, 58, 59,61, 62, 64, 66, 67, 68, 69, 70, 71, 72, 73, 81, 82, 83, 84, 89, IS39).
- §Pre-specified type-specific prevalence at baseline: HPV 6 = 0.028, HPV11 = 0.034, HPV16 = 0.047, HPV18 = 0.019, HPV26 = 0.022, HPV31 = 0.015, HPV33 = 0.013, HPV35 = 0.023, HPV39 = 0.011, HPV40 = 0.018, HPV42 = 0.025, HPV45 = 0.020, HPV51 = 0.041, HPV52 = 0.036, HPV53 = 0.058, HPV54 = 0.038, HPV55 = 0.024, HPV56 = 0.023, HPV58 = 0.014, HPV59 = 0.030, HPV61 = 0.040, HPV62 = 0.065, HPV64 = 0.002, HPV66 = 0.034, HPV67 = 0.013, HPV68 = 0.016, HPV69 = 0.027, HPV70 = 0.020, HPV71 = 0.056, HPV72 = 0.012, HPV73 = 0.015, HPV81 = 0.027, HPV82 = 0.054, HPV83 = 0.041, HPV84 =0.048, HPV89 = 0.047, HPVIS39 = 0.014.
- Reduced: vaccine types (HPV 6, 11, 16, 18) are reduced 50%.