No. of HPV types* | Time§ | Pre-specified true composite prevalence (SD) | Composite prevalence estimate (SD) | Est. to true ratio | Composite prevalence estimate (SD) | Est. to true ratio | Composite prevalence estimate (SD) | Est. to true ratio | Composite prevalence estimate (SD) | Est. to true ratio |
---|---|---|---|---|---|---|---|---|---|---|
a: Sensitivity ≤ Specificity | ||||||||||
Sen.= 0.95 | Sen. = 0.90 | Sen. = 0.85 | Sen. = 0.80 | |||||||
Spe.= 0.95 | Spe. = 0.95 | Spe. = 0.95 | Spe. = 0.95 | |||||||
2 | Baseline | 0.064 (0.004) | 0.151 (0.006) | 2.359 | 0.148 (0.005) | 2.313 | 0.146 (0.006) | 2.281 | 0.143 (0.005) | 2.234 |
Reduced | 0.032 (0.003) | 0.125 (0.005) | 3.906 | 0.123 (0.005) | 3.843 | 0.121 (0.005) | 3.781 | 0.120 (0.005) | 3.750 | |
% red. | 50 | 17.2 | 16.9 | 17.1 | 13.9 | |||||
4 | Baseline | 0.120 (0.005) | 0.275 (0.007) | 2.292 | 0.269 (0.007) | 2.242 | 0.264 (0.007) | 2.200 | 0.260 (0.007) | 2.167 |
Reduced | 0.062 (0.004) | 0.229 (0.007) | 3.694 | 0.227 (0.006) | 3.661 | 0.224 (0.007) | 3.613 | 0.222 (0.006) | 3.581 | |
% red. | 48 | 16.7 | 15.6 | 15.2 | 14.6 | |||||
14 | Baseline | 0.282 (0.007) | 0.616 (0.007) | 2.184 | 0.609 (0.008) | 2.160 | 0.603 (0.008) | 2.138 | 0.596 (0.008) | 2.113 |
Reduced | 0.259 (0.007) | 0.604 (0.008) | 2.332 | 0.599 (0.008) | 2.313 | 0.593 (0.008) | 2.290 | 0.587 (0.008) | 2.266 | |
% red. | 8.2 | 1.9 | 1.6 | 1.7 | 1.5 | |||||
37 | Baseline | 0.617 (0.008) | 0.904 (0.004) | 1.465 | 0.900 (0.005) | 1.459 | 0.895 (0.005) | 1.451 | 0.891 (0.005) | 1.444 |
Reduced | 0.596 (0.008) | 0.899 (0.005) | 1.508 | 0.895 (0.005) | 1.502 | 0.891 (0.005) | 1.495 | 0.887 (0.005) | 1.488 | |
% red. | 3.4 | 0.5 | 0.6 | 0.4 | 0.4 | |||||
b: Sensitivity ≥ Specificity | ||||||||||
Sen. = 0.95 | Sen. = 0.95 | Sen. = 0.95 | Sen. = 0.95 | |||||||
Spe. = 0.95 | Spe. = 0.90 | Spe. = 0.85 | Spe. = 0.80 | |||||||
2 | Baseline | 0.064 (0.004) | 0.151 (0.006) | 2.359 | 0.237 (0.007) | 3.703 | 0.318 (0.007) | 4.969 | 0.394 (0.008) | 6.156 |
Reduced | 0.032 (0.003) | 0.125 (0.005) | 3.906 | 0.213 (0.006) | 6.656 | 0.297 (0.007) | 9.281 | 0.374 (0.008) | 11.688 | |
% red. | 50 | 17.2 | 10.1 | 6.6 | 5.1 | |||||
4 | Baseline | 0.120 (0.005) | 0.275 (0.007) | 2.292 | 0.409 (0.008) | 3.408 | 0.525 (0.008) | 4.375 | 0.621 (0.008) | 5.175 |
Reduced | 0.062 (0.004) | 0.229 (0.007) | 3.694 | 0.374 (0.008) | 6.033 | 0.496 (0.008) | 8.000 | 0.598 (0.008) | 9.645 | |
% red. | 48 | 16.7 | 8.6 | 5.5 | 3.7 | |||||
14 | Baseline | 0.282 (0.007) | 0.616 (0.008) | 2.184 | 0.797 (0.006) | 2.826 | 0.895 (0.005) | 3.174 | 0.947 (0.004) | 3.358 |
Reduced | 0.259 (0.006) | 0.604 (0.008) | 2.332 | 0.792 (0.006) | 3.058 | 0.892 (0.005) | 3.444 | 0.945 (0.004) | 3.649 | |
% red. | 8.2 | 1.9 | 0.6 | 0.3 | 0.2 | |||||
37 | Baseline | 0.617 (0.008) | 0.904 (0.004) | 1.465 | 0.975 (0.002) | 1.580 | 0.993 (0.001) | 1.609 | 0.998 (0.007) | 1.515 |
Reduced | 0.596 (0.008) | 0.899 (0.005) | 1.508 | 0.974 (0.003) | 1.634 | 0.993 (0.001) | 1.666 | 0.998 (0.007) | 1.674 | |
% red. | 3.4 | 0.5 | 0.1 | 0 | 0 |