Figure 2

Alignment of the deduced amino acid sequences of domain HA1 of subtype H3 of viral isolates found in Uberlândia. Sequences of H3N2 viruses of samples collected from 2001 to 2007 were compared to the strains of the vaccine available in each corresponding year: A/Moscow/10/99 (accession number DQ487341; 2001–2003 vaccine), A/Fujian/411/2002 (accession number CY112933; 2004 vaccine), A/Wellington/1/2004 (accession number CY012104; 2005 vaccine), A/California/7/2004 (accession number CY114373; 2006 vaccine), and A/Wisconsin/67/2005 (accession number CY114381; 2007 vaccine). Residues that match the residues of the vaccine strain sequence, which is shown at the top of each group of sequences separated by time period, are represented by dots and those that diverge are shown, N-linked glycosylation sites are marked by dashed boxes (including loss of a glycosylation site), residues involved in receptor binding are shaded, sialic acid binding site is underlined and the antigenic sites A-E are shown as open boxes. The numbering above the alignment represents the positions of amino acid residues of H3 protein according to the reference sequence A/Taiwan/30005/2004(H3N2) (accession number DQ249261).