Characteristics
|
Patients
|
---|
Age, years
|
66 (52–78)
|
Female/male
|
127 (48)/140 (52)
|
Nursing home resident
|
4 (1.5)
|
Patients with any comorbidity
|
172 (64)
|
Atherosclerosisa
|
71 (27)
|
COPD
|
60 (23)
|
Immune disorderb
|
34 (13)
|
Diabetes mellitus
|
33 (12)
|
Renal disease
|
32 (12)
|
Asthma
|
25 (9)
|
Congestive heart failure
|
22 (8)
|
Neurologicalc
|
19 (7)
|
Dementia
|
15 (6)
|
Active malignancy
|
13 (5)
|
Innate or acquired immunodeficiencyd
|
11 (4)
|
Liver disease
|
4 (1.5)
|
Active smoker
|
65 (24)
|
Travel historye
|
37 (15)
|
Pneumococcal vaccinef
|
25 (13)
|
Influenza vaccinef
|
66 (33)
|
Antibiotics prior to hospital admissionf
|
90 (36)
|
Immunosuppressive drugsg
|
37 (14)
|
- Note: Values are presented as No. (%) or median (25th–75th percentile). COPD, chronic obstructive pulmonary disease.
- aCoronary heart disease, cerebrovascular disease and/or peripheral artery disease.
- bEleven patients with rheumatoid arthritis, 1 patient with systemic lupus erythematosus, 6 patients with inflammatory bowel disease, 1 patient with autoimmune hepatitis, 3 patients with Sjogren’s disease, 14 patients with psoriasis (2 patients had 2 conditions).
- cCentral nervous disease and/or neuromuscular disease.
- dOne patient with antibody deficiency, 1 patient with HIV, 1 patient with heart transplant, 2 patients with kidney transplant, 1 patient with bone marrow transplant. Three patients had received chemotherapy and 2 had received radiation therapy within last 3 months.
- eTravel abroad past 4 weeks.
- fVaccinated against pneumococcus within previous 10 years; vaccinated against influenza virus within previous 12 months; antibiotics within previous 3 months.
- gImmunosuppressive drugs were defined as any use of systemic steroids, Azathioprine, TNF-alpha inhibitor, Cyclosporine, Cyclophosphamide and/or Methotrexate within previous 3 months.