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Table 2 Characteristics of patients included in the analysis and comparison between patients found within a large cluster (≥10 patients) or with a transmission link to patients without these observed connections for determined associations with P-value ≤ 0.1

From: Bridging epidemiology with population genetics in a low incidence MSM-driven HIV-1 subtype B epidemic in Central Europe

 

Total population

%

In cluster (n ≥ 10)

%

Not in cluster

%

P-value2

With a local transmission link (n = 2–39)

%

No link

%

P-value2

Patients

            
  

223

52.2%1

146

65.5%

77

34.5%

 

180

80.7%

43

19.3%

 

Gender

             
 

Male

210

94.2%

141

67.1%

69

32.9%

0.0761

170

81.0%

40

19.0%

0.9488

 

Female

13

5.8%

5

38.5%

8

61.5%

 

10

76.9%

3

23.1%

 

Year of diagnosis

            
 

2000–2004

45

20.2%

23

51.1%

22

48.9%

0.0388

31

68.9%

14

31.1%

0.0479

 

2005–2008

86

38.6%

60

69.8%

26

30.2%

0.3555

74

86.0%

12

14.0%

0.1514

 

2009–2012

92

41.3%

63

68.5%

29

31.5%

0.5178

75

81.5%

17

18.5%

0.9391

Country of origin

            
 

Slovenia

174

78.0%

122

70.1%

52

29.9%

0.2919

148

85.0%

26

15.0%

0.0479

 

Other

15

6.7%

8

53.3%

7

46.7%

 

9

60.0%

6

40.0%

 
 

Unknown

34

15.3%

16

47.1%

18

52.9%

 

23

67.6%

11

32.4%

 

Origin of the virus3

            
 

Slovenia

131

58.7%

105

80.2%

26

19.8%

<0.0001 4

120

91.6%

11

8.4%

<0.0001 4

 

Other

36

16.1%

11

30.6%

25

69.4%

 

19

52.7%

17

46.3%

 
 

Unknown

56

25.1%

30

53.6%

26

46.4%

 

41

73.2%

15

26.8%

 

SDRMs

            
 

Detected

8

3.6%

2

25.0%

6

75.0%

0.0431

3

37.5%

5

62.5%

0.0153

 

Not detected

215

96.4%

144

67.0%

71

33.0%

 

177

82.3%

38

17.7%

 
  1. 1proportion among all newly diagnosed HIV-1 patients in the period 2000–2012 in Slovenia.
  2. 2for significance testing, the Fisher exact test was employed for categorical data and t-statistics for continuous data. P-values ≤ 0.05 are shown in bold.
  3. 3the origin of the virus is determined according to the country where the infection most probably occurred, as reported in the patients’ questionnaires.
  4. 4significant characteristic after employing a Bonferroni correction, at a significance level of <0.0033.
  5. SDRMs = surveillance for drug resistance mutations, n = number of patients in a transmission cluster.