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Table 4 Most common serotypes among pneumococcal meningitis isolates in Germany among children <16 years (1992/93-2005/06, n = 777; 2007/08-2009/10, n = 227; 2010/11-2012/13, n = 194)

From: Pneumococcal meningitis and vaccine effects in the era of conjugate vaccination: results of 20 years of nationwide surveillance in Germany

Children

1992/93-2005/06

2007/08-2009/10

2010/11-2012/13

P values

Serotypes

(n)

%

(n)

%

(n)

%

Pre PCV 7 vs post PCV7+13

Pre PCV7 vs post PCV7

Post PCV7 vs post PCV13

4

27

3.5

1

0.4

0

0.0

0.0002↓

0.0105↓

1.0000

6B

71

9.1

10

4.4

4

2.1

0.0001↓

0.0188↓

0.2755↓

9V

13

1.7

2

0.9

0

0.0

0.1015↓

0.5414↓

0.5019↓

14

184

23.7

11

4.8

0

0.0

<0.0001↓

<0.0001↓

0.0012↓

18C

66

8.5

18

7.9

2

1.0

0.0186↓

0.8918↓

0.0008↓

19F

72

9.3

5

2.2

5

2.6

<0.0001↓

0.0002↓

1.0000

23F

53

6.8

5

2.2

1

0.5

<0.0001↓

0.0088↓

0.2241↓

PCV 7

486

62.5

52

22.9

12

6.2

<0.0001↓

<0.0001↓

<0.0001↓

1

22

2.8

16

7.0

1

0.5

0.3062↑

0.0087↑

0.0007↓

5

4

0.5

0

0.0

1

0.5

0.6624↓

0.5799↓

0.4608↑

7F

49

6.3

38

16.7

17

8.8

0.0001↑

<0.0001↑

0.0197↓

PCV10

561

72.2

106

46.7

31

16.0

<0.0001↓

<0.0001↓

<0.0001↓

3

15

1.9

11

4.8

11

5.7

0.0025↑

0.0287↑

0.8269↑

6A

34

4.4

11

4.8

1

0.5

0.2106↑

0.7184↑

0.0074↓

19A

19

2.4

9

4.0

14

7.2

0.0084↑

0.2504↑

0.1961↑

PCV13

629

81.0

137

60.4

57

29.4

<0.0001↓

<0.0001↓

<0.0001↓

2

1

0.1

0

0.0

0

0.0

1.0000

1.0000

1.0000

8

10

1.3

5

2.2

4

2.1

0.3323↑

0.3497↑

1.0000

9N

6

0.8

3

1.3

3

1.5

0.3624↑

0.4309↑

1.0000

10A

14

1.8

8

3.5

14

7.2

0.0021↑

0.1255↑

0.1230↑

11A

7

0.9

1

0.4

5

2.6

0.3969↑

0.6912↓

0.0991↑

12F

3

0.4

5

2.2

12

6.2

<0.0001↑

0.0174↑

0.0472↑

15B

7

0.9

4

1.8

4

2.1

0.1734↑

0.2811↑

1.0000

17F

3

0.4

3

1.3

0

0.0

0.4295↑

0.1329↑

0.2528↓

20

2

0.3

0

0.0

0

0.0

0.5438↓

1.0000

1.0000

22F

5

0.6

10

4.4

8

4.1

<0.0001↑

0.0003↑

1.0000

33F

8

1.0

3

1.3

5

2.6

0.2906↑

0.7189↑

0.4793↑

PPV23

729

93.8

199

87.7

137

70.6

<0.0001↓

0.6504↓

<0.0001↓

6C

4

0.5

2

0.9

3

1.5

0.2917↑

0.6226↑

0.6653↑

15C

5

0.6

9

4.0

11

5.7

<0.0001↑

0.0009↑

0.4930↑

23A

4

0.5

4

1.8

3

1.5

0.0588↑

0.0826↑

1.0000

23B

2

0.3

1

0.4

14

7.2

<0.0001↑

0.5369↑

0.0002↑

35B

1

0.1

2

0.9

8

4.1

0.0002↑

0.1300↑

0.0492↑

others

66

8.5

30

13.2

43

22.2

<0.0001↑

0.0388↑

0.0201↑

NVT

82

10.6

48

21.1

82

42.3

<0.0001↑

0.0001↑

<0.0001↑

  1. Corrected for multiple comparisons using the Dunn-Šidák test (β = 0.000732493). Arrows indicate increasing or decreasing percentage of serotypes post vaccination.
  2. PCV7: serotypes 4, 6B, 9V, 14, 18C, 19F, 23F; PCV10: PCV7 + serotypes 1, 5, 7F; PCV13: PCV10 + serotypes 3, 6A, 19A; PPV23: PCV13 + serotypes 2, 8, 9N, 10A, 11A, 12F, 15B, 17F, 20, 22F, 33F, but without serotyp 6A; NVT: non-vaccine types, i.e. serotypes not included in any of the above mentioned vaccines.
  3. Significant P values are printed in bold.
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BMC Infectious Diseases

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