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Table 5 Key modified sites between the classical clade 2.3.2 and clade 2.3.2.1 virus, China

From: Spatial, temporal and genetic dynamics of highly pathogenic avian influenza A (H5N1) virus in China

Clade   Codon position
18 61 69 136 156 178 196 242 279
Classical 2.3.2 Gln (100%) Asp (97.96%) Arg (97.96%) Ser (97.96%) Ser (91.84%) Arg (95.92%) Asn (53.06%) Met (95.92%) Ala (100%)
2.3.2.1 His (100%) Asn (91.67%) Lys (100%) Asp (95.83%) Asn (93.75%) Lys (100%) Asp (95.83%) Ile (100%) Thr (91.67%)
  1. Note. Based on the results of Figure 7a and b, we conclude that the virus may have escaped from the vaccine in sites 118–137, 130–160 and 161–179. Table 3 indicates that site 156 received selective pressure with 95% probability. The table summarizes the key sites that varied from the classical clade 2.3.2 virus to clade 2.3.2.1 virus.