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Table 5 Key modified sites between the classical clade 2.3.2 and clade 2.3.2.1 virus, China

From: Spatial, temporal and genetic dynamics of highly pathogenic avian influenza A (H5N1) virus in China

Clade

 

Codon position

18

61

69

136

156

178

196

242

279

Classical 2.3.2

Gln (100%)

Asp (97.96%)

Arg (97.96%)

Ser (97.96%)

Ser (91.84%)

Arg (95.92%)

Asn (53.06%)

Met (95.92%)

Ala (100%)

2.3.2.1

His (100%)

Asn (91.67%)

Lys (100%)

Asp (95.83%)

Asn (93.75%)

Lys (100%)

Asp (95.83%)

Ile (100%)

Thr (91.67%)

  1. Note. Based on the results of Figure 7a and b, we conclude that the virus may have escaped from the vaccine in sites 118–137, 130–160 and 161–179. Table 3 indicates that site 156 received selective pressure with 95% probability. The table summarizes the key sites that varied from the classical clade 2.3.2 virus to clade 2.3.2.1 virus.