Figure 1

Comparison of miRNA-29a/b/c levels in HIV-1-infected patients (n = 58) and gender- and age-matched healthy donors (HD) (n = 21). MiRNA-29a/b/c levels were analysed in PBMC collected from HIV-1-infected patients and from healthy individuals using real time RT-PCR assays. MiRNA-29a/b/c levels are expressed as relative expression [ΔCt method] normalized to the levels of the constitutively expressed RNU6B. The relative quantity of miRNA-29a/b/c levels was calculated by the equation 2 − (ΔCt). Differences between HIV-1-infected patients and healthy donors in terms of miRNA-29 levels were analysed using the Mann–Whitney test. (°HIV-1-infected patients vs healthy donors: miRNA-29a, p = 0.251; miRNA-29b, p < 0.0001. miRNA-29c, p = 0.164). Kruskal-Wallis test was used to evaluate differences in expression among miRNA-29a/b/c in HIV-1-infected individuals and healthy subjects (*HIV-1-infected patients: p < 0.001; **healthy donors: p < 0.001).