Table 3 Characteristics of the episodes of severe sepsis: Sequential data from 2006 to 2011

Men

59.2% (58.7, 59.8)

58.8% (58.3, 59.3)

58.4% (57.9, 58.9)

58.4% (57.9, 58.8)

57.8%(57.3, 58.3)

57.2% (56.8, 57.7)

Age

62.7 ± 0.15

63.9 ± 0.13

64.6 ± 0.12

65.7 ± 0.11

67.0 ± 0.11

67.6 ± 0.10

Men

61.2 ± 0.19

62.6 ± 0.16

63.2 ± 0.16

64.5 ± 0.14

65.9 ± 0.14

66.1 ± 0.13

Women

64.8 ± 0.23

65.7 ± 0.19

66.7 ± 0.17

67.5 ± 0.16

68.5 ± 0.17

69.5 ± 0.16

Age groups

<18 y

9.7% (9.4, 10.0)

8.6% (8.3, 8.9)

8.1% (7.9, 8.4)

7.3% (7.1, 7.5)

6.6% (6.3, 6.8)

6% (5.8, 6.3)

18-64 y

28.5% (28.0, 29.0)

28.1% (27.6, 28.6)

27.7% (27.3, 28.1)

26.8% (26.4, 27.2)

25.6% (25.2, 26.0)

25.7% (25.3, 26.0)

>64 y

61.8% (61.2, 62.4)

63.3% (62.8, 63.8)

64.2% (63.7, 64.6)

65.9% (65.5, 66.3)

67.8% (67.4, 68.2)

68.3% (67.9, 68.7)

Diagnostic categories

Medical

75.3% (74.8, 75.8)

75.1%(74.7, 75.6)

72.8%(72.3, 73.2)

73.1% (72.7, 73.5)

74.1% (73.7, 74.5)

74.8% (74.4, 75.2)

Surgical

24.7% (24.2, 25.2)

24.9%(24.4, 25.3)

27.2% (26.8, 27.7)

26.9% (26.5, 27.3)

25.9% (25.5, 26.3)

25.2% (24.8, 25.6)

Charlson index

1.76 ± 0.01

1.73 ± 0.01

1.84 ± 0.01

1.90 ± 0.01

1.91 ± 0.01

1.95 ± 0.01

Comorbidities

Cancer (non-metastatic)

17.0% (16.6, 17.4)

16.8%(16.4, 17.2)

16.7% (16.3, 17.1)

17% (16.6, 17.4)

17.2% (16.8, 17.5)

17.7% (17.3, 18.0)

COPD^a

12.9% (12.5, 13.3)

13.2%(12.8, 13.6)

13.4% (13.1, 13.7)

13.9% (13.6, 14.2)

13.3% (13.0, 13.7)

13.2% (12.9, 13.5)

Chronic cardiac failure

12.5% (12.1, 12.9)

13.1% (12.8, 13.5)

13.9% (13.5, 14.2)

14.6% (14.3, 14.9)

14.9% (14.5, 15.2)

15.4% (15.1, 15.7)

Chronic renal disease

8.8% (8.5, 9.2)

8.8% (8.5, 9.1)

13.3% (13.0, 13.6)

14.9% (14.5, 15.2)

15.4% (15.0, 15.7)

16.1% (15.8, 16.4)

Cerebrovascular

8.4% (8.1, 8.8)

8.1% (7.8, 8.4)

8.3% (8.0, 8.5)

8.4% (8.0, 8.5)

8.4% (8.1, 8.6)

8.3% (8.1, 8.6)

Cancer with metastasis

5.6% (5.3, 5.9)

5.5% (5.3, 5.7)

5.7% (5.4, 5.9)

5.8% (5.6, 6.1)

6.3% (6.1, 6.5)

6.4% (6.2, 6.6)

Number of organ dysfunctions

1

55.1% (54.5, 55.6)

54.1% (53.6, 54.7)

53.9% (53.4, 54.3)

53.1% (52.6, 53.5)

53.9% (53.4, 54.3)

52.0% (51.6, 52.4)

2

26.8% (26.3, 27.3)

26.2% (25.7, 26.7)

25.9% (25.5, 26.3)

26.1% (25.6, 26.5)

25.5% (25.1. 25.9)

26.4% (26.0, 26.8)

≥3

18.2% (17.7, 18.6)

19.7% (19.3, 20.1)

20.3% (19.9, 20.6)

20.9% (20.5, 21.3)

20.7% (20.3, 21.0)

21.6% (21.3, 22.0)

Type of organ dysfunction ^b

Respiratory

51.9% (51.4, 52.5)

52.3% (51.8, 52.8)

51.6% (51.1, 52.1)

51.6% (51.1, 52.0)

48.9% (48.4, 49.4)

47.7% (47.3, 48.1)

Cardiovascular

45.9% (45.3, 46.4)

47.0% (46.5, 47.5)

45.9% (45.4, 46.4)

44.4% (44.0, 44.9)

43.9% (43.4, 44.3)

42.8% (42.3, 43.2)

Renal

36.5% (36.0, 37.1)

37.0% (36.5, 37.6)

38.2% (37.7, 38.6)

40.1% (39.6, 40.5)

41.7% (41.3, 42.2)

46.5% (46.1, 47.0)

Hepatic

5.3% (5.1, 5.6)

5.2% (5.0, 5.5)

5.4% (5.2, 5.7)

5.4% (5.2, 5.7)

5.1% (4.9, 5.3)

4.9% (4.7, 5.1)

Metabolic

7.4% (7.1, 7.7)

7.2% (7.0, 7.5)

7.8% (7.5, 8.0)

8.7% (8.4, 8.9)

8.7% (8.5, 9.0)

9.4% (9.1, 9.6)

Neurologic

10.6% (10.3, 11.0)

10.6% (10.3, 11.0)

10.8% (10.5, 11.1)

11.2% (10.9, 11.5)

11.1% (10.8, 11.4)

11.2% (11.0, 11.5)

Hematolologic

11.1% (10.7, 11.5)

11.0% (10.7, 11.4)

11.8% (11.5, 12.1)

11.8% (11.5, 12.1)

11.9% (11.6, 12.2)

12.4% (12.1, 12.7)

Identified Germs ^b

Yes

26.9% (26.4, 27.4)

25.6% (25.1, 26.0)

25.4% (25.0, 25.8)

24.8% (24.4, 25.2)

25.8% (25.4, 26.2)

26.1% (25.8, 26.5)

Gram positive

39.4% (38.4, 40.5)

39.2% (38.2, 40.3)

39.1% (38.2, 40.1)

37.3% (36.4, 38.3)

35.1% (34.3, 36.0)

33.6% (32.8, 34.4)

Gram-negative

56.3% (55.2, 57.4)

56.3% (55.2, 57.3)

58.1% (57.1, 59.0)

59.2% (58.3, 60.1)

62.4% (61.5, 63.3)

64.5% (63.7, 65.4)

Anaerobic

1.5% (1.2, 1.8)

1.5% (1.3, 1.8)

1.4% (1.2, 1.7)

1.7% (1.5, 2.0)

1.5% (1.3, 1.8)

1.8% (1.6, 2.0)

Fungus

9.4% (8.7, 10.0)

8.7% (8.1, 9.3)

7.4% (6.9, 7.9)

7% (6.5, 7.5)

6.8% (6.3, 7.2)

6.1% (5.8, 6.6)

Bacteremia

18% (17.6, 18.5)

16.4% (16.0, 16.8)

16.2% (15.9, 16.6)

16.4% (16.0, 16.7)

16.2% (15.9, 16.6)

16.4% (16.0, 16.7)

Length of stay (days)

24.8 ± 0.19

24.5 ± 0.17

24.1 ± 0.16

23.1 ± 0.14

21.9 ± 0.13

21.0 ± 0.12

Case-fatality

45.4% (44.9, 46.0)

45.9% (45.4, 46.5)

43.6% (43.1, 44.1)

42.9% (42.5, 43.4)

41.5% (41.0, 41.9)

40.2% (39.8. 40.6)