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Table 4 Subgroup and sensitivity analyses

From: A meta-analysis of ventriculostomy-associated cerebrospinal fluid infections

Comparison n Infections/1000 catheter-days Lower 95% CI a Upper 95% CI p I-squared (%)
Overall 35 11.4 9.3 13.5 0.004 44
Subgroups
Culture frequency
Daily culture 5 10.8 4.8 16.8 0.16 39
Culture when indicated 15 11.2 8.6 13.9 0.16 27
Other culture regimes 15 13.5 9.6 17.4 0.048 41
Infection definition
Culture proven infection 18 11.5 8.4 14.6 0.004 54
CDC definition of infection 5 8.8 6.3 11.3 0.403 0.50
Culture plus other features 5 9.1 4.8 13.4 0.436 0
Culture or other features 7 17 10 24.1 0.347 11
Age group       
Paediatric 3 10.6 6.1 15.2 0.429 0
Adult 32 11.5 9.3 13.7 0.002 48
Year       
Publication year <2000 5 18.3 12.4 24.3 0.39 3
Publication year 2000+ 30 10.5 8.4 12.6 0.002 47
Duration       
Mean duration <7 days 6 19.6 10 24.1 0.6 0
Mean duration 7-10 days 14 12.8 9.5 16 0.03 49
Mean duration >10 days 15 8 5.4 10.5 0.106 37
Study type       
Prospective 5 11 6.6 15.4 0.23 29
Retrospective 30 11.4 9.1 13.8 0.003 47
AIC       
No AIC 18 10.8 8.1 13.6 0.001 57
Unclear 13 13.7 9.8 17.6 0.19 25
AIC used 4 7.2 2.6 14.1 0.64 0
Sensitivity Analysis
Study size       
<=1000 catheter-days 13 18.3 13.4 23.3 0.34 11
>1000 catheter-days 22 9 6.8 11.2 0.027 40
Newcastle-Ottawa score
1 and 2 11 13.5 8.9 18.1 0.046 46
3 and 4 24 10.6 8.3 13 0.019 41
  1. aCI = confidence interval.