From: A meta-analysis of ventriculostomy-associated cerebrospinal fluid infections
Comparison | n | Infections/1000 catheter-days | Lower 95% CI a | Upper 95% CI | p | I-squared (%) |
---|---|---|---|---|---|---|
Overall | 35 | 11.4 | 9.3 | 13.5 | 0.004 | 44 |
Subgroups | ||||||
Culture frequency | ||||||
Daily culture | 5 | 10.8 | 4.8 | 16.8 | 0.16 | 39 |
Culture when indicated | 15 | 11.2 | 8.6 | 13.9 | 0.16 | 27 |
Other culture regimes | 15 | 13.5 | 9.6 | 17.4 | 0.048 | 41 |
Infection definition | ||||||
Culture proven infection | 18 | 11.5 | 8.4 | 14.6 | 0.004 | 54 |
CDC definition of infection | 5 | 8.8 | 6.3 | 11.3 | 0.403 | 0.50 |
Culture plus other features | 5 | 9.1 | 4.8 | 13.4 | 0.436 | 0 |
Culture or other features | 7 | 17 | 10 | 24.1 | 0.347 | 11 |
Age group | Â | Â | Â | Â | Â | Â |
Paediatric | 3 | 10.6 | 6.1 | 15.2 | 0.429 | 0 |
Adult | 32 | 11.5 | 9.3 | 13.7 | 0.002 | 48 |
Year | Â | Â | Â | Â | Â | Â |
Publication year <2000 | 5 | 18.3 | 12.4 | 24.3 | 0.39 | 3 |
Publication year 2000+ | 30 | 10.5 | 8.4 | 12.6 | 0.002 | 47 |
Duration | Â | Â | Â | Â | Â | Â |
Mean duration <7 days | 6 | 19.6 | 10 | 24.1 | 0.6 | 0 |
Mean duration 7-10 days | 14 | 12.8 | 9.5 | 16 | 0.03 | 49 |
Mean duration >10 days | 15 | 8 | 5.4 | 10.5 | 0.106 | 37 |
Study type | Â | Â | Â | Â | Â | Â |
Prospective | 5 | 11 | 6.6 | 15.4 | 0.23 | 29 |
Retrospective | 30 | 11.4 | 9.1 | 13.8 | 0.003 | 47 |
AIC | Â | Â | Â | Â | Â | Â |
No AIC | 18 | 10.8 | 8.1 | 13.6 | 0.001 | 57 |
Unclear | 13 | 13.7 | 9.8 | 17.6 | 0.19 | 25 |
AIC used | 4 | 7.2 | 2.6 | 14.1 | 0.64 | 0 |
Sensitivity Analysis | ||||||
Study size | Â | Â | Â | Â | Â | Â |
<=1000 catheter-days | 13 | 18.3 | 13.4 | 23.3 | 0.34 | 11 |
>1000 catheter-days | 22 | 9 | 6.8 | 11.2 | 0.027 | 40 |
Newcastle-Ottawa score | ||||||
1 and 2 | 11 | 13.5 | 8.9 | 18.1 | 0.046 | 46 |
3 and 4 | 24 | 10.6 | 8.3 | 13 | 0.019 | 41 |