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Table 6 Demography, history, and physical parameters of female patients investigated in the safety set

From: Review of the literature and individual patients’ data meta-analysis on efficacy and tolerance of nitroxoline in the treatment of uncomplicated urinary tract infections

  Nitroxoline Controls p-value
Demographic parameter n Median (range) n Median (range)  
Age (years) 234 48 (18–89) 232 47 (18–85) 0.520
-up to 45 years 234 113 (48.3%) 232 115 (49.6%) 0.745
Height (cm) 234 165 (150–185) 231 165 (145–187) 0.290
Weight (kg) 234 62 (43–100) 232 64 (42–102) 0.125
Body mass index (kg /m2) 234 23.0 (15.9–41.3) 231 23.2 (15.6–38.0) 0.038
Heart rate (min −1) 231 80 (52–172) 231 80 (56–120) 0.354
Systolic BP (mmHg) 232 120 (80–195) 231 130 (100–190) 0.025
Diastolic BP (mmHg) 232 80 (60–120) 231 80 (50–120) 0.410
No hypertension (SBP ≤ 140 mmHG) 232 165 (71.1%) 231 137 (59.3%) 0.004
Mild hypertension (SBP > 140 mmHG) 232 46 (19.8%) 231 63 (27.3%)  
Moderate hypertension (SBP > 160 mmHG) 232 17 (7.3%) 231 22 (9.5%)  
Severe hypertension (SBP > 180 mmHG) 232 4 (1.7%) 231 9 (3.9%)  
Diabetes mellitus 234 11 (4.7%) 232 6 (2.6%) 0.230
Duration of urinary symptoms (d) 165 3 (1–30) 168 3 (1–21) 0.442
Pretreatment with antimicrobials* 234 16 (6.8%) 232 8 (3.4%) 0.060
Only unspecific pretreatment# 234 25 (10.7%) 232 28 (12.1%) 0.667
  1. *antibiotics, chemotherapeutics.
  2. #spasmolytics, analgetics, tea etc.