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Table 11 Adverse events

From: Review of the literature and individual patients’ data meta-analysis on efficacy and tolerance of nitroxoline in the treatment of uncomplicated urinary tract infections

Adverse events (AE)   Nitroxoline Controls
  Patients (total) 234 (100%) 232 (100%)
  Patients with AEs# 23 (9.8%) 18 (7.8%)
Adverse events (total)   33 26
Nervous system disorders Headache 3 4
  Dizziness - 3
Eye disorders Eyelid swelling 1 -
Cardiac and circulation disorders Circulation disorder - 1
Gastrointestinal disorders Dysgeusia - 1
  Nausea 9 3
  Regurgitation 1 1
  Gastralgia 4 3
  Obstipation - 1
  Diarrhoea 5 -
Metabolim and nutrition disorder Anorexia 1 -
Urinary disorders Incontinence 1 -
Reproductive system disorders Colpitis 1 1
  Fluor vaginalis 1 -
  Tubal tumor - 1
Immune system disorders Allergy 1* 1
Skin and subcutaneous tissue disorders Itching 1 1
  Urticaria 1 1
  Herpes labialis - 1
General disorders Intolerance 1 -
  Weakness 1 -
  Fever 1 -
Musculoskeletal, connective tissue and bone disorders Back pain - 1
  Flank pain - 2
  Leg pain - 1
  1. #comparison of nitroxoline vs. controls (logistic regression with random center effect) p = 0.360; *with papules/pustules.