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Table 2 Discrepant analyses of 11 samples that were array-positive but culture-negative

From: Rapid detection of dermatophytes and Candida albicansin onychomycosis specimens by an oligonucleotide array

Sample Fungus detected by ITS cloning (%)a KOH mount/tinea pedisb Improvement after treatment Final interpretation of the array result
  Culture Array  
C26 Aspergillus sp. Trichophyton rubrum T. rubrum (99.8) ND/+c (follw-up loss) True positive
C27 (negative) T. rubrum T. rubrum (99.2) ND/+ Yes True positive
C28 Penicillium sp. T. rubrum (negative) -/- (follw-up loss) False positive
C29 Cladosporium sp. T. rubrum T. rubrum (100) ND/+ Yes True positive
C30 (negative) T. rubrum T. rubrum (100) ND/- (follw-up loss) True positive
C32 Candida sp. T. rubrum T. rubrum (99.6) +/- Yes True positive
C36 (negative) C. albicans (negative) -/- Yesc False positive
C38 (negative) T. rubrum T. rubrum (100) +/+ Yes True positive
C46 (negative) T. rubrum (negative) +/+ (follw-up loss) True positive
C49 (negative) T. rubrum (negative) +/+ Yes True positive
C50 (negative) T. rubrum T. rubrum (100) +/+ Yes True positive
  1. aValues in parentheses are percentages of sequence similarities of the determined sequences with the best-scoring sequences in public database.
  2. bND, not determined. +, KOH mount positive or the corresponding patient was positive for tinea pedis. -, KOH mount negative or the corresponding patient was negative for tinea pedis.
  3. cThe patient was not treated with antifungals, but his onychomycosis completely resolved in the follow-up visit.