Rapid detection of dermatophytes and Candida albicansin onychomycosis specimens by an oligonucleotide array

BMC Infectious Diseases

Table 2 Discrepant analyses of 11 samples that were array-positive but culture-negative

Sample	Fungus detected by		ITS cloning (%)^a	KOH mount/tinea pedis^b	Improvement after treatment	Final interpretation of the array result
	Culture	Array		KOH mount/tinea pedis^b	Improvement after treatment	Final interpretation of the array result
C26	Aspergillus sp.	Trichophyton rubrum	T. rubrum (99.8)	ND/+^c	(follw-up loss)	True positive
C27	(negative)	T. rubrum	T. rubrum (99.2)	ND/+	Yes	True positive
C28	Penicillium sp.	T. rubrum	(negative)	-/-	(follw-up loss)	False positive
C29	Cladosporium sp.	T. rubrum	T. rubrum (100)	ND/+	Yes	True positive
C30	(negative)	T. rubrum	T. rubrum (100)	ND/-	(follw-up loss)	True positive
C32	Candida sp.	T. rubrum	T. rubrum (99.6)	+/-	Yes	True positive
C36	(negative)	C. albicans	(negative)	-/-	Yes^c	False positive
C38	(negative)	T. rubrum	T. rubrum (100)	+/+	Yes	True positive
C46	(negative)	T. rubrum	(negative)	+/+	(follw-up loss)	True positive
C49	(negative)	T. rubrum	(negative)	+/+	Yes	True positive
C50	(negative)	T. rubrum	T. rubrum (100)	+/+	Yes	True positive

^aValues in parentheses are percentages of sequence similarities of the determined sequences with the best-scoring sequences in public database.
^bND, not determined. +, KOH mount positive or the corresponding patient was positive for tinea pedis. -, KOH mount negative or the corresponding patient was negative for tinea pedis.
^cThe patient was not treated with antifungals, but his onychomycosis completely resolved in the follow-up visit.

ISSN: 1471-2334