Direct susceptibility testing for multi drug resistant tuberculosis: A meta-analysis

BMC Infectious Diseases

Table 2 Description of meta-analysed reports (n = 18)

Test	Author, (Year)	Ref	Reference test	Country	Sample Size	Rifampicin				Isoniazid				Time (Days)
						TR	FR	FS	TS	TR	FR	FS	TS
NRA	Affolabi D (2008)	[6]	L-J PM	Benin	144	6	1	0	137	14	1	0	129	18
	Affolabi D (2007)	[7]	L-J PM	Benin	177	7	0	1	169	0	0	0	0	28
	Solis LA (2005)	[8]	L-J PM	Peru	192	113	0	1	78	101	0	7	84	28
	Musa HR (2005)	[9]	L-J PM	Argentina	121	11	0	0	110	13	0	1	107	18
	TOTAL				634	137	1	2	494	128	1	8	320
MODS	Ejigu GS (2008)	[10]	MGIT 960	Ethopia	58	19	0	1	38	32	2	1	23	15
	Mello FCQ (2007)	[13]	L-J PM	Honduras	180	72	18	3	87	89	19	3	69	24
	Shiferaw G (2007)	[14]	Agar PM	Ethopia	247/246	24	1	2	220	50	6	3	187	29
	Moore DAJ (2006)	[11]	L-J PM	Peru	338/334	36	0	0	302	64	1	10	259	15
	Moore DAJ (2004)	[15]	MABA-MIC	Peru	276	31	7	2	236	63	8	10	195	ND
	Caviedes L (2000)	[16]	MABA-MIC	Peru	88	16	9	0	63	22	1	0	65	ND
	TOTAL				1187/1182	198	35	8	946	320	37	27	798
Genotype ^® MTBDR	Hillemann D (2007)	[18]	L-J PM	Germany	71	30	1	1	39	36	0	5	30	ND
	Somoskovi A (2006)	[19]	BACT 460	USA	130	25	3	0	102	50	0	38	47	ND
	Hillemann D (2006)	[20]	L-J PM	Germany	42	15	0	0	27	17	0	0	25	ND
	TOTAL				243	70	4	1	168	103	0	43	102
Genotype ^® MTBDR *plus*	Causse M (2008)	[21]	MGIT 960	Spain	18	9	0	0	9	8	0	0	10	ND
	Lacoma A (2008)	[22]	BACT 460	Spain	51	29	1	0	21	28	0	2	21	ND
	Miotto P (2008)	[23]	Sequencing	Italy	173/172	20	0	0	153	117	0	0	55	ND
	Barnard M (2008)	[24]	MGIT 960	S. Afrrica	454/452	94	2	1	357	114	1	7	330	2
	Hillemann D (2007)	[18]	L-J PM	Germany	71	30	1	1	39	37	0	4	30	ND
	TOTAL				767/764	182	4	2	579	304	1	13	446

Abbreviations:BACT 460 = Radiometric BACTEC 460, FS = false susceptible, FR – false resistant, L-J PM = Proportion method on Lowenstein-Jensen medium, MGIT = Mycobacterium growth indicator tube, MODS = Microscopic Observation drug susceptibility assay; ND = No data in study report, NRA = Nitrate Reductase Assay, Ref = Bibliographic reference, Time = Duration in days from setting the test to obtaining 100% of the results in the specified study, TS = true susceptible, TR = true resistant. The MODS assay has been studied on both smear positive and smear negative sputum samples with good results, which is not the case with any other tests.

ISSN: 1471-2334