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Table 2 Description of meta-analysed reports (n = 18)

From: Direct susceptibility testing for multi drug resistant tuberculosis: A meta-analysis

Test Author, (Year) Ref Reference test Country Sample Size Rifampicin Isoniazid Time (Days)
       TR FR FS TS TR FR FS TS  
NRA Affolabi D (2008) [6] L-J PM Benin 144 6 1 0 137 14 1 0 129 18
  Affolabi D (2007) [7] L-J PM Benin 177 7 0 1 169 0 0 0 0 28
  Solis LA (2005) [8] L-J PM Peru 192 113 0 1 78 101 0 7 84 28
  Musa HR (2005) [9] L-J PM Argentina 121 11 0 0 110 13 0 1 107 18
  TOTAL     634 137 1 2 494 128 1 8 320  
MODS Ejigu GS (2008) [10] MGIT 960 Ethopia 58 19 0 1 38 32 2 1 23 15
  Mello FCQ (2007) [13] L-J PM Honduras 180 72 18 3 87 89 19 3 69 24
  Shiferaw G (2007) [14] Agar PM Ethopia 247/246 24 1 2 220 50 6 3 187 29
  Moore DAJ (2006) [11] L-J PM Peru 338/334 36 0 0 302 64 1 10 259 15
  Moore DAJ (2004) [15] MABA-MIC Peru 276 31 7 2 236 63 8 10 195 ND
  Caviedes L (2000) [16] MABA-MIC Peru 88 16 9 0 63 22 1 0 65 ND
  TOTAL     1187/1182 198 35 8 946 320 37 27 798  
Genotype ® MTBDR Hillemann D (2007) [18] L-J PM Germany 71 30 1 1 39 36 0 5 30 ND
  Somoskovi A (2006) [19] BACT 460 USA 130 25 3 0 102 50 0 38 47 ND
  Hillemann D (2006) [20] L-J PM Germany 42 15 0 0 27 17 0 0 25 ND
  TOTAL     243 70 4 1 168 103 0 43 102  
Genotype ® MTBDR plus Causse M (2008) [21] MGIT 960 Spain 18 9 0 0 9 8 0 0 10 ND
  Lacoma A (2008) [22] BACT 460 Spain 51 29 1 0 21 28 0 2 21 ND
  Miotto P (2008) [23] Sequencing Italy 173/172 20 0 0 153 117 0 0 55 ND
  Barnard M (2008) [24] MGIT 960 S. Afrrica 454/452 94 2 1 357 114 1 7 330 2
  Hillemann D (2007) [18] L-J PM Germany 71 30 1 1 39 37 0 4 30 ND
  TOTAL     767/764 182 4 2 579 304 1 13 446  
  1. Abbreviations:BACT 460 = Radiometric BACTEC 460, FS = false susceptible, FR – false resistant, L-J PM = Proportion method on Lowenstein-Jensen medium, MGIT = Mycobacterium growth indicator tube, MODS = Microscopic Observation drug susceptibility assay; ND = No data in study report, NRA = Nitrate Reductase Assay, Ref = Bibliographic reference, Time = Duration in days from setting the test to obtaining 100% of the results in the specified study, TS = true susceptible, TR = true resistant. The MODS assay has been studied on both smear positive and smear negative sputum samples with good results, which is not the case with any other tests.