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Table 2 Univariate and Multivariate analysis of factors associated with unfavorable outcome

From: Hyperglycemia in bacterial meningitis: a prospective cohort study

Characteristic Odds ratio (95% CI) (univariate) P Odds ratio (95% CI) (multivariate) P
Age, yrs 1.47 (1.35–1.62) <0.0001 1.16 (1.03–1.16) 0.01
Known diabetes 2.24 (1.23–4.11) <0.01 0.96 (0.42–2.16) 0.9
Immunocompromised, not diabetes 2.92 (1.76–4.90) <0.0001 1.15 (0.61–2.17) 0.7
Heart rate     
   < 60 bpm 2.26 (0.73–6.58) <0.01 4.95 (1.09–22.45) 0.04
   60–90 bpm 1.00 (reference)   1.00 (reference)  
   >90–120 bpm 1.62 (1.09–2.44)   1.23 (0.75–2.01) 0.4
   >120 bpm 3.96 (2.51–6.31) <0.001 2.44 (1.35–4.43) 0.003
Diastolic blood pressure 0.97 (0.92–1.01) 0.01 0.95 (0.90–1.01) 0.09
Glasgow Coma Scale 0.82 (0.78–0.86) <0.001 0.87 (0.81–0.93) <0.001
Distant focus of infection* 2.05 (1.48–2.84) <0.0001 1.04 (0.67–1.63) 0.9
Focal neurologic deficits# 2.50 (1.80–3.48) <0.0001 1.93 (1.28–2.90) 0.002
Blood glucose 0.87 (0.69–1.07) 0.001 0.93 (0.75–1.16) 0.5
Log platelet count 0.62 (0.50–0.76) <0.001 0.62 (0.48–0.81) <0.001
Log CSF leukocyte count 0.80 (0.75–0.85) <0.001 0.80 (0.74–0.87) <0.001
Causative organism     
   S. pneumoniae 7.65 (5.02–12.00) <0.0001 4.95 (2.69–9.12) <0.001
   N. meningitidis 1.00 (reference)   1.00 (reference)  
   Other 3.98 (2.22–7.17) <0.001 2.38 (1.12–5.04) 0.02
  1. * Defined as otitis/sinusitis or pneumonia. # Defined as cranial nerve palsies, aphasia, monoparesis or hemiparesis. Bpm denotes beats per minute, CSF cerebrospinal fluid.