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Table 3 Univariate and multivariate influence of HIV status and Sex on Lam Sensitivity

From: Low sensitivity of a urine LAM-ELISA in the diagnosis of pulmonary tuberculosis

    Univariate Results Multivariate Results
Covariate Stratum n Prevalence ratio for specificity (95% CI) p-value Prevalence ratio for specificity (95% CI) p-value
HIV status         
  Negative 19 1    1   
  Positive 50 2.945 (1.193–7.272) 0.019 2.619 (1.045 – 6.561) 0.040
Sex         
  Female 30 1    1   
  Male 39 0.577 (0.359 – 0.927) 0.023 0.694 (0.440 – 1.097) 0.118
  1. The results of a Poisson regression included only gold standard positive participants. The outcome variable (sensitivity) was coded as 1 for true positive LAM results and as 0 for false negative LAM results. Apart from age and sex no other predictors were included into the multivariate model.
  2. Prevalence ratio for specificity = probability to receive a (correct) positive LAM result for TB infected patients who are HIV+ve or male, divided by probability to receive a (correct) positive LAM result for TB infected patients who are HIV-ve or female.
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