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Table 1 The clinical findings of probable CJD patients in Korea with codons 178, 200-129, and 232 mutations.

From: Mutations at codons 178, 200-129, and 232 contributed to the inherited prion diseases in Korean patients

Patient Case 1 Case 2 Case 3
Age of onset 67 58 65
Mutation D178N-129M E200K-129MV M232R
Sex M M M
Symptoms of onset Progressive gait disturbance
Dysarthria
Extrapyramidal sign
Gait disturbance
Confused mentality
Dysarthria
Agitation
Myoclonus
Memory decline
Gait disturbance
Total clinical duration Alive (27 months)* 3 months 16 months
MRI imaging
(DWI or FLAIR)
High signal intensities in both parietal and occipital gyri High signal intensity on bilateral frontotemporoparietal area and caudate nucleus High signal intensities from the cortex of the parieto-occipital and the temporal lobes
EEG finding Normal Sharp or spike and slow waves Diffuse theta to delta range slow waves
14-3-3 protein in CSF Positive Positive Positive
  1. * As of May 2008