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Table 1 Effect of BCG vaccination of UK teenagers on IFN-γ responses to mycobacterial and control antigens. n= 148 (control group n = 62, vaccine group n = 86) except Ag85 where n= 43 (baseline), 50 (3 months), 49 (12 months).

From: Persistence of the immune response induced by BCG vaccination

   Time after vaccination
   Baseline 3 months 12 months
Antigen Control Vaccinated Control Vaccinated Control Vaccinated
M.tb PPD % responders 23 19 31 87 19 74
  Median pg/ml (IQ range) 0 (0–60) 0 (0–36) 0 (0–103) 488 (150–1178) 0 (0–46) 214 (57–822)
p value Vaccinated versus Control 0.5 < 0.001 < 0.001
M.tb Ag85 % responders 78 72 90 100 62 96
  Median pg/ml (IQ range) 184 (61–721) 168 (45–426) 813 (221–1340) 1192 (865–2353) 112 (0–262) 808 (386–1865)
p value Vaccinated versus Control 0.67 0.09 0.002
RPMI % responders 5 7 8 6 3 6
  Median pg/ml (IQ range) 15 (15) 15 (15) 15 (15) 15 (15) 15 (15) 15 (15)
PHA % responders 97 100 98 97 87 86
  Median pg/ml (IQ range) 2940 (1432–3692) 3200 (2225–4700) 3807 (1496–4529) 3578 (2610–4092) 2578 (314–3357) 2797 (548–4202)
p value Vaccinated versus Control 0.09 0.76 0.85