Multiplex cytokine profile from dengue patients: MIP-1beta and IFN-gamma as predictive factors for severity

BMC Infectious Diseases

Table 1 Demographic information about the study population with dengue fever.

Characteristics	Mild¹		Severe		Fisher's exact test
Age (median years, 25–75%) ²	39, 28–48		37, 23–53
Sex (M:F) (Patient Number)	7:13		26:13
DENV-1: DENV-3 (Patient Number)	20:0		8:31		p < 0.0001
	% ³	N ⁴	%	N
Fever	30	20	8	37
Haemorrhagic manifestations⁵	35	20	41	37
Petechia	21	19	49	37
Abdominal Pain	19	16	33	36
Thrombocytopenia (<100.000 counts/mm³)	63	19	72	39
Thrombocytopenia (<50.000 counts/mm³)	0	19	46	39
Hipotension⁶	0	20	67	39
Hemoconcentration⁷	33	15	10	39
Secondary Infection	26	19	42	33	P = 0.37

¹See Methods for mild and severe dengue definition.
²Study population with 59 patients with 3–10 days of disease onset.
³Percentage of positive patients for the measured parameter within the group.
⁴Number of patients used for the measured parameter within the group.
⁵Epistaxis, gengivorrhagia, positive tourniquet test, metrorrhagia, bleeding after coughing.
⁶Postural hypotension with decrease in systolic arterial pressure in 20 mmHg in supine position or systolic arterial pressure < 90 mmHg.
⁷Elevated hematocrit for matched age and sex (women>41%; men >45%) or fluctuation of packed cell volume ≥ 20% during course of illness and recovery.

ISSN: 1471-2334