Table 3 Risk factors for resistance development, drug susceptibility testing, antituberculous therapy
From: Extensively drug resistant tuberculosis in a high income country: A report of four unrelated cases
Patient 1 | Patient 2 | Patient 3 | Patient 4 | |
|---|---|---|---|---|
Risk factors for resistance development: | ||||
Necessity of closed ward treatment | yes | yes | yes | no |
Antituberculous treatment before immigration | yes, regimen unknown | yes, including 9 months of RMP monotherapy | yes, regimen unknown | yes, regimen unknown |
Drug susceptibility testing at time of Immigration: | ||||
Resistant | INH, RMP, RFB, EMB, PZA, SM, Eto, Cs, Tsc, Clr, Cfz | INH, RMP, EMB, SM, Pto | INH, EMB | - |
Intermediate | PAS | - | - | - |
Susceptible | Am, CM, Ofx | PZA, Cs, Cfx | RMP, PZA, SM | INH, RMP, EMB, PZA, SM |
Drug susceptibility testing at time of XDR Diagnosis: | ||||
Resistant | INH, RMP, EMB, SM, Cm, Ofx, Eto, Pto, Cs, PAS, Tsc | INH, RMP, RFB, EMB, SM, CM, Cfx, Amx/Clv, Tsc | INH, RMP, RFB, EMB, PZA, Cm, Am, Ofx, Eto, Cs, Cfz, Tsc | INH, RMP, PZA, SM, Am, Cm, Cfx, Amx/Clv, Cfz, Tsc |
Intermediate | PZA | Pto | - | - |
Susceptible | Mxf, Cfz | PZA, Am, Mxf, Cs, Cfz, Lzd | SM, PAS, Clr | EMB, Mxf, Pto, Cs, PAS, Lzd |
Antituberculous drugs used during therapy of XDR TB | PZA, Mxf, Pto, Cfz | PZA, Am, Mxf, Lzd | RFB, PZA, SM, Am, Cm, Ofx, Pto, Trd, PAS, Cfz, Amx/Clv, Clr, Doxycyclin | EMB, PZA, Am, Mxf, Cfx, Pto, Trd, Lzd |
Non pharmacologic treatment | right upper lobectomy and atypical left upper lobectomy | right upper lobe resection 01/03 + left upper lobe and left lower lobe segmental resection 04/03 | left sided pneumonectomy |