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Table 4 NP isolates and resistance to TMP-SMX and other selected antimicrobials

From: High incidence of antimicrobial resistant organisms including extended spectrum beta-lactamase producing Enterobacteriaceae and methicillin-resistant Staphylococcus aureusin nasopharyngeal and blood isolates of HIV-infected children from Cape Town, South Africa

Organisms isolated Resistant to TMP-SMX Resistance to selected antibiotics
S. pneumoniae 43 (89.6%) Pen 20 (41.7%)# CTX 1 (2.1%)
Gram negative respiratory   
H. influenzae 20 (80%) Amp 3 (12%); Amox/clav 1 (4%)
M. catarrhalis 2 (18.2%) Δ † Beta-lactamase +ve 12 (85.7%)
S. aureus 40 (91%) Clox – 34 (77.3%) Gent 36 (81.8%), Amik – 0
Enterobacteriaceae 29 (90.6%) CTX 16 (50%); Gent 18 (56%); Amik 5 (15.6%); PTZ 10 – 31.3%) Mero – 0
Pseudomonas 0 Gent – 1 (20%); Amik – 0
  1. Clox – cloxacillin, Gent – gentamicin, Amik – amikacin, Pen – penicillin; CTX – cefotaxime; Amp – ampicillin, Amox/clav – amoxicillin-clavulanate
  2. # S. pneumoniae – MIC performed in 18 isolates: 7 (38.9%) fully sensitive (MIC ≤ 0.06 μg/ml) 9 (50%) with intermediate resistance (MIC 0.12 – 1 μg/ml) and 2 (11.1%) with high level resistance (MIC ≥2 mg/ml) to penicillin
  3. M. catarrhalis: Δ 11 isolates tested for MIC; † 14 of 17 isolates tested for beta-lactamase production. No significant differences for resistance to penicillin, cloxacillin, cefotaxime, gentamicin, amikacin and TMP-SMX by present or previous exposure to TMP-SMX
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