|
Artemether ir*, single dose
|
2.08 (0.42 – 5)
|
6.7 ± 1.19
|
6.7 ± 1.19
|
6.7 ± 1.19
|
|
Artemisinin ir, single dose
|
19 (4 – 41)
|
20.0 ± 0
|
20.0 ± 0
|
20.0 ± 0
|
|
Artemisinin ir, multiple dose
|
20 (0.7 – 62)
|
31.5 ± 8
|
45.1 ± 14
|
45.1 ± 14
|
|
Artesunate ir, multiple dose
|
19 (1.3 – 80)
|
6.65 ± 4
|
8.1 ± 4.17
|
14.8 ± 7.64
|
|
Artesunate ir, single dose – 10 mg/kg
|
12 (1.33 – 58)
|
9.4 ± 2.47
|
9.4 ± 2.47
|
9.4 ± 2.53
|
|
Artesunate per os
|
6 (0.92 – 15)
|
4.0 ± 0
|
4.0 ± 0
|
4.0 ± 0
|
|
Artemisinins parenteral
|
18 (0.5 – 66)
|
2.94 ± 0.61
|
2.94 ± .0.6
|
3.43 ± 0.99
|
|
Quinine parenteral
|
3 (0.3 – 49)
|
17.6 ± 4.31
|
24.2 ± 4.96
|
36.6 ± 5.7
|
|
Quinine parenteral + Artesunate ir
|
45 (32 – 60)
|
-
|
-
|
-
|
|
Artesunate ir, single – 20 mg/kg
|
6.3 (2 – 30)
|
19.4 ± 1.63
|
19.4 ± 1.63
|
20.7 ± 0.99
|
