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Table 2 Summary of Age and Doses used in clinical trials by type of therapy(mg/kg)

From: Rectal artemisinins for malaria: a review of efficacy and safety from individual patient data in clinical studies

Treatment group Median age, years (range) Dose(mg/kg) at Initiation of therapy (mean ± SD) Total dose over first 12 hours (mg/kg) (mean ± SD) Total dose over first 24 hours (mg/kg) (mean ± SD)
Artemether ir*, single dose 2.08 (0.42 – 5) 6.7 ± 1.19 6.7 ± 1.19 6.7 ± 1.19
Artemisinin ir, single dose 19 (4 – 41) 20.0 ± 0 20.0 ± 0 20.0 ± 0
Artemisinin ir, multiple dose 20 (0.7 – 62) 31.5 ± 8 45.1 ± 14 45.1 ± 14
Artesunate ir, multiple dose 19 (1.3 – 80) 6.65 ± 4 8.1 ± 4.17 14.8 ± 7.64
Artesunate ir, single dose – 10 mg/kg 12 (1.33 – 58) 9.4 ± 2.47 9.4 ± 2.47 9.4 ± 2.53
Artesunate per os 6 (0.92 – 15) 4.0 ± 0 4.0 ± 0 4.0 ± 0
Artemisinins parenteral 18 (0.5 – 66) 2.94 ± 0.61 2.94 ± .0.6 3.43 ± 0.99
Quinine parenteral 3 (0.3 – 49) 17.6 ± 4.31 24.2 ± 4.96 36.6 ± 5.7
Quinine parenteral + Artesunate ir 45 (32 – 60) - - -
Artesunate ir, single – 20 mg/kg 6.3 (2 – 30) 19.4 ± 1.63 19.4 ± 1.63 20.7 ± 0.99
  1. * ir: Intra-rectal