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Table 1 Parameter values used for simultations and calculations

From: Low-level HIV-1 replication and the dynamics of the resting CD4+T cell reservoir for HIV-1 in the setting of HAART

Parameter Definition Valuesa References
δ P Net death rate of productively infected cells 0.50 (0.5–0.693) day-1 [32, 65, 66]
δ L b Net death rate of latently infected cells 0.0001 (0.001–0.0001) day-1 [32]
δ U Net death rate of target cells 0.02 (1.0–0.001) day-1 [32, 67]
α Q Activation rate of latently infected cells 0.0005 (0.001–0.0001) day-1 [36]
α R c Rate of reversion of productively infected cells to latency α Q 100 MathType@MTEF@5@5@+=feaagaart1ev2aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacPC6xNi=xH8viVGI8Gi=hEeeu0xXdbba9frFj0xb9qqpG0dXdb9aspeI8k8fiI+fsY=rqGqVepae9pg0db9vqaiVgFr0xfr=xfr=xc9adbaqaaeGacaGaaiaabeqaaeqabiWaaaGcbaqcfa4aaSGaaeaaiiGacqWFXoqydaWgaaqaaiabdgfarbqabaaabaGaeGymaeJaeGimaaJaeGimaadaaaaa@3231@ [3, 32, 68, 69]
λ Production rate of target cells 2 × 109 cells/day Approximated from the steady-state condition that U ¯ MathType@MTEF@5@5@+=feaagaart1ev2aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacPC6xNi=xH8viVGI8Gi=hEeeu0xXdbba9frFj0xb9qqpG0dXdb9aspeI8k8fiI+fsY=rqGqVepae9pg0db9vqaiVgFr0xfr=xfr=xc9adbaqaaeGacaGaaiaabeqaaeqabiWaaaGcbaGafmyvauLbaebaaaa@2D1E@ = 1 × 1011 in the case of no infection. Also consistent with [70]
L U ¯ MathType@MTEF@5@5@+=feaagaart1ev2aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacPC6xNi=xH8viVGI8Gi=hEeeu0xXdbba9frFj0xb9qqpG0dXdb9aspeI8k8fiI+fsY=rqGqVepae9pg0db9vqaiVgFr0xfr=xfr=xc9adbaqaaeGacaGaaiaabeqaaeqabiWaaaGcbaqcfa4aaSGaaeaacqWGmbataeaacuWGvbqvgaqeaaaaaaa@2EDF@ Ratio of latently infected cells to target cells 10-4 (10-4–10-6) [2, 4]
  1. aRanges tested in parentheses
  2. bEstimated based on resting cell death rate
  3. cEstimated based on the ratio of latently infected cells to productively infected cells
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BMC Infectious Diseases

ISSN: 1471-2334

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