Table 5 Molecular expression and oxidative stress studies.
Parameter | Month | IFN gamma | Placebo | p (Student's t) |
|---|---|---|---|---|
Oxidative stress | N = 10 | N = 8 | ||
SOD (U/mL/min) | 0 | 36.2 ± 17.8 | 27.2 ± 11.5 | 0.23 |
6 | 28.6 ± 12.6 | 29.8 ± 16.5 | 0.85 | |
P (6 vs 0) | 0.034 | 0.612 | ||
AOPP (μM) | 0 | 71.3 ± 35.2 | 60.8 ± 34.5 | 0.46 |
6 | 48.4 ± 15.2 | 65.7 ± 27.6 | 0.12 | |
P (6 vs 0) | 0.008 | 0.734 | ||
Genetic modulation (relative to GAPDH × 100) | N = 8 | N = 6 | ||
TGF beta | 0 | 113 ± 37 | 113 ± 29 | 0.99 |
6 | 152 ± 106 | 235 ± 232 | 0.80 | |
p (6 vs 0) | 0.401 | 0.028 | ||
TNF alpha | 0 | 37 ± 35 | 68 ± 21 | 0.080 |
6 | 37 ± 34 | 81 ± 28 | 0.025 | |
p (6 vs 0) | 0.946 | 0.370 | ||
MCP-1 | 0 | 112 ± 58 | 38 ± 29 | 0.015 |
6 | 59 ± 27 | 69 ± 39 | 0.60 | |
p (6 vs 0) | 0.032 | 0.244 |