Table 7 Sample of erroneous answers discovered in databases
Category | Question | Correct answer used for assessment | Erroneous answer(s) | Database(s) |
|---|---|---|---|---|
Dosing | What is the recommended dosing regimen for fosamprenavir in a protease inhibitor-experienced HIV+ patient who wants once daily dosing? | Once daily dosing is not recommended for this type of patient | • 700 mg by mouth once daily plus ritonavir 100 mg twice daily for PI experienced patients | • PPDC |
Adverse Drug Reaction | Can ethionamide cause impotence? | Yes, but it is a rare ADR. | • Listed as a common reaction | • JHAG |
Method of Administration | How do you administer Synagis? | Remove flip top from Synagis vial and wipe rubber stopper with a disinfectant (e.g., 70% isopropyl alcohol). Insert needle into vial, and withdraw into syringe an appropriate volume of solution. Administer immediately after drawing dose into syringe. Synagis is supplied as single-dose vial and does not contain preservatives. Do not re-enter vial after withdrawal of drug; discard unused portion. Only administer one dose per vial. | • Provides information about scheduling multiple patients for multiple injections from same vial to minimize waste | • CP |
Indication | Should amantadine be given as prophylaxis against influenza A? | It should not be used in the 2007–2008 influenza season due to resistance. | • Provides pediatric dosing information for this indication • Lists influenza A prophylaxis as an indication | • PPDC • DM • IDI |
Drug-Food interaction | How should didanosine be taken in regards to food? | Didanosine should be taken on an empty stomach at least 30 minutes before or 2 hours after food. Do not take didanosine or didanosine EC with food. | • Provides contradictory information: States that didanosine can be taken with or without food in one sentence and the following statement states to take on an empty stomach 30 minutes before or 2 hours after food. | • EOF • EOP • DIO |